银杏去甲基酮酯对激光诱导脉络膜新生血管恒河猴模型的药效学研究OA

Objective:To explore the inhibitory effect of Ginkgo Demethylketone Ester on laser-induced choroidal neovascularization(CNV)in rhesus monkeys.Methods:Sixteen healthy rhesus monkeys received bilateral fundus laser photocoagulation to establish CNV models.The subjects were divided into four groups:the placebo group(n=6),the conbercept injection group(n=3),the Ginkgo leaf extract group(n=3),and the Ginkgo Demethylketone Ester group(n=4).Fundus photography(FP),fundus fluorescein angiography(FFA),and optical coherence tomography(OCT)were conducted at baseline(D0,before administration)and on day 28(D28)after administration.The primary efficacy endpoints included:1)the number of grade IV lesions,2)the change rate of fluorescein leakage area in grade IV lesions,and 3)the change rate of retinal thickness in grade IV lesions.Results:In Placebo group,there were 30 grade IV lesions.The change rates of the fluorescein leakage area and retinal thickness were(101.7±84.3)%and(64.7±91.5)%respectively.In conbercept group(0.5 mg/eye),there were 20 grade IV lesions.The change rates of fluorescein leakage area and retinal thickness were(-100.0±0.0)%,and(-94.1±14.3)%respectively.In Ginkgo leaf extract group,there were 24 grade IV lesions.The change rates of the fluorescein leakage area and retinal thickness were(-19.9±76.23)%,and(3.0±102.03)%respectively.In Ginkgo Demethylketone Ester group,there were 26 grade IV lesions.The change rates of the fluorescein leakage area and retinal thickness were(-34.7±53.3)%,and(-58.6±48.5)%respectively.The Ginkgo Demethylketone Ester group showed statistically significant differences from the placebo group in all endpoints.Conclusions:Ginkgo Demethylketone Ester significantly improved fluorescein leakage and retinal thickening in the rhesus monkey CNV model.