基于外泌体的肺部靶向递送:间充质干细胞外泌体雾化吸入治疗在呼吸系统疾病的研究与转化挑战OA

Mesenchymal stem cell-derived exosomes(MSC-Exos)have attracted attention due to their rich bioactive substances and low immunogenic properties.Nebulization inhalation,as a non-invasive and targeted pulmonary delivery method,has opened up new avenues for the application of MSC-Exos in respiratory diseases.This article systematically reviews the characteristics of MSC-Exos,the mechanisms of nebulization inhalation,as well as the efficacy in respiratory diseases,the challenges faced in clinical translation,and the future development directions,aiming to provide a theoretical basis for the preclinical research and clinical translation of this emerging therapeutic strategy.