基于数据挖掘从"阳明蓄血"理论探讨岳仁宋教授治疗2型糖尿病相关认知功能障碍用药经验OA

Objective To summarize Professor Yue Rensong's medication experience in treating type 2 diabetes-associated cognitive dysfunction(TDACD)using data mining techniques.Methods Prescription data of TDACD patients who visited Professor Yue Rensong's outpatient clinic at Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from December 2023 to October 2025 and met the inclusion criteria were collected.RStudio software was used for a systematic analysis of the frequency of Chinese herbal medicines,their four natures and five flavors,meridian tropism,association rules,and cluster analysis,and the data were visualized.Results A total of 114 prescriptions involving 198 Chinese herbs were collected.Regarding the four natures,warm,cold,and neutral herbs were dominant;in terms of five flavors,sweet,bitter,and pungent herbs were primarily used;for meridian tropism,herbs mainly targeted the liver,spleen,lung,stomach,and kidney,followed by the heart and large intestine meridians.Association rule analysis identified 37 pairs of herb combinations and 54 core herb pairs(support>0.2).Cluster analysis revealed three groups of core herb combinations corresponding to the formulas Didang Tang,Changpu Yujin Tang,and Shenqi Dihuang Tang.Conclusion Professor Yue Rensong believes that TDACD is characterized by a complex pathogenesis involving a mixture of deficiency and excess,with intertwined blood stasis and turbid toxins.Its disease progression includes the whole process from early-stage Yangming blood accumulation with turbid blood disturbing the clear orifices to late-stage deficiency of both Qi and Yin,kidney deficiency,and marrow depletion.In treatment,he emphasizes the combined use of cold and warm medicines as well as purgation and tonification,taking unblocking the bowels and removing blood stasis,opening the orifices and restoring consciousness,and tonifying the kidney to replenish essence as the basic strategies,and selecting corresponding core prescriptions according to different syndrome patterns.For patients with more severe conditions,he stresses the principle of"heavy dosage to treat severe diseases".This study summarizes Professor Yue Rensong's clinical medication patterns in the treatment of TDACD,providing certain ideas for clinical syndrome differentiation and treatment.