川崎病病儿ITPKC和CASP3基因多态性对冠状动脉损伤易感性诊断价值OA

Objective To investigate the association between ITPKC/CASP3 gene polymorphisms and susceptibility to coronary artery injury in children with Kawasaki disease,as well as their value in the diagnosis of coronary artery injury.Me-thods The children with Kawasaki disease who were admitted to The First Affiliated Hospital of Xinxiang Medical College from June 2020 to June 2023 were enrolled as subjects,among whom 31 with coronary artery injury were enrolled as study group,and 31 children without coronary artery injury who were treated during the same period of time were enrolled as control group.The two groups were compared in terms of genotype and allele frequencies at the rs28493229 locus of the ITPKC gene and the rs113420705 locus of the CASP3 gene,and dominant model,recessive model,and additive model were used to investigate the efficacy of diffe-rent genotypes in predicting coronary artery injury in children.Results There were significant differences between the two groups in genotype distribution and allele frequency at the rs28493229 locus of the ITPKC gene and the rs113420705 locus of the CASP3 gene(x2=6.332-6.923,all P＜0.05).In the dominant,recessive,and additive models,the risk assessment of the AA genotype of the CASP3 gene and the CC genotype of the ITPKC gene showed significant differences between the two groups(OR=0.452-0.922,95％CI=0.200-0.300 to 0.752-0.997,all P＜0.05).Conclusion ITPKC/CASP3 gene polymorphisms are closely as-sociated with the susceptibility to coronary artery injury in children with Kawasaki disease,and the analysis of gene polymorphisms has a potential value in predicting the diagnosis of coronary artery injury in such children.