基于液滴微流控技术的水凝胶材料及其在类器官中的应用研究进展OA
Research progress on hydrogel materials based on droplet microfluidic technology and their application in organoids structure
类器官培养过程存在操作复杂、均一性差、成本高、低通量等局限,液滴微流控搭载新型水凝胶材料因高通量、重复性好、保留异质性等优势,为其提供了新策略.本文系统综述了基于液滴微流控技术的水凝胶材料及其在类器官中的应用进展,分析了未来液滴微流控平台一体化集成、水凝胶材料的动态响应性调控及配套高通量分析技术等的发展方向,以期为新药研发、精准医学和再生医学,提供新的研究思路和技术平台.
Organoid culture has long been confronted with bottlenecks such as complex operation,poor uniformity,high cost and low throughput.Droplet microfluidics equipped with novel hydrogel materials provides a new strategy due to its advantages of high throughput,good repeatability and retention of heterogeneity.This article systematically reviews the progress of hydrogel materials based on droplet microfluidic technology and their applications in organoids.Then,it analyzes the future development directions of integrated integration of droplet microfluidic platforms,dynamic responsiveness regulation of hydrogel materials,and supporting high-throughput analysis technologies to provide new research ideas and technical platforms for new drug development,precision medicine and regenera-tive medicine.
冯国萌;王恩民;王思媛;王若雨;于炜婷
大连大学附属中山医院肿瘤实验室,大连 116001大连大学附属中山医院肿瘤实验室,大连 116001大连大学附属中山医院肿瘤实验室,大连 116001大连大学附属中山医院肿瘤实验室,大连 116001大连大学附属中山医院中心实验室,大连 116001
医药卫生
液滴微流控水凝胶类器官高通量筛选再生医学
Droplet microfluidicsHydrogelOrganoidHigh-throughput screeningRegenerative medicine
《生物医学工程研究》 2026 (1)
58-64,7
国家自然科学基金项目(82172822).
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