基于非门控胸部CT的冠状动脉钙化与冠状动脉狭窄程度相关性OA

Objective To investigate the association of coronary artery calcification(CAC)assessed by non-gated chest CT with coronary heart disease(CHD)and the severity of coronary artery stenosis.Methods A retrospective analysis was per-formed for 2 105 patients suspected of CHD who underwent both invasive coronary angiography and chest CT examination in Huai'an No.1 People's Hospital Affiliated to Nanjing Medical University from January to December 2022.According to the Agat-ston score,the patients were divided into non-calcification group,mild calcification group,moderate calcification group,and severe calcification group.The 528 patients with coronary artery stenosis ≤50％were included in the control group,while the 1 577 pa-tients with coronary artery stenosis＞50％were included in the CHD group.Baseline data and CAC distribution were compared be-tween the two groups.The multivariate logistic regression analysis was used to investigate the association between CAC and CHD,and the chi-square test was used to analyze the correlation between CAC and the severity of stenosis.Results Compared with the control group,the CHD group had significantly higher age,proportion of male patients,smoking rate,prevalence rate of dia-betes,and level of triglyceride(x2=15.935-34.498,Z=—4.925,—2.863,P＜0.05).The degree of CAC was significantly associ-ated with CHD(x2=297.480,P＜0.001).The severity of coronary artery stenosis increased significantly with the increase in the degree of calcification(x2=437.641,P＜0.001).CAC was an independent risk factor for CHD,and the risk of developing CHD in the mild,moderate,and severe calcification groups was 3.39,11.46,and 27.39 times,respectively,that in the non-calcification group(P＜0.001).Conclusion CAC assessed by non-gated chest CT is significantly associated with CHD and the severity of coronary artery stenosis,which provides a reference for the diagnosis of CHD and the assessment of disease severity.