大米发酵滤液与燕窝酸的协同光保护作用研究OA

A UVA-induced skin fibroblast damage model was established using UVA irradiation to evaluate the photoprotective effects of combining rice fermentation filtrate(RFF)and sialic acid(SA).The biological effects of RFF and SA alone and together were systematically analyzed by measuring cell viability,reactive oxygen species(ROS)levels,adenosine triphosphate(ATP)and nicotinamide adenine dinucleotide(NAD+)content,as well as mitochondrial membrane potential.The results showed that the combination of RFF and SA significantly enhanced cellular antioxidant capacity,inhibited ROS production,promoted the synthesis of key energy metabolism substances such as ATP and NAD+,and protected mitochondrial membrane potential,consequently improving mitochondrial function.Compared to single treatments,the combined group exhibited superior performance in multiple indicators,exhibiting a clear synergistic effect.These findings provide a theoretical basis and experimental support for the joint application of RFF and SA in the development of photoprotective cosmetic products.