视黄醇棕榈酸酯醇质体的制备及其表征研究OA

Retinyl palmitate phytosomes(RP-E)were prepared using ultra-high-pressure microfluidization.Characterization showed that the phytosomes were spherical or ellipsoidal,exhibiting a phospholipid bilayer structure.The average particle size was 39.18 nm(PDI=0.143),and the zeta potential was-37.95 mV,indicating excellent dispersion stability.HPLC analysis confirmed the RP content of 4.99%,and ultracentrifugation revealed an encapsulation efficiency of 99.8%.Stability studies demonstrated that particle sizes remained below 50 nm under various storage conditions(room temperature,light exposure,-15 ℃,45℃,alternating temperature,and 5℃),and the active ingredient content exceeded 4.5%under all conditions except 45 ℃ and alternating temperature,corresponding to degradation rates below 10%.This process not only effectively protects retinol derivatives but also shows strong potential for industrial-scale production,providing an innovative strategy for nano-encapsulation of retinoid raw materials.