电阻抗断层成像与脑电同步检测系统研发及其在癫痫病灶定位中的可行性研究OA
Development of an EIT-EEG synchronous detection system and feasibility study for epileptic zone localization
针对难治性癫痫病灶精准定位的问题,本研究研发了电阻抗断层成像(EIT)与脑电(EEG)信号同步检测系统,以验证EIT在致痫灶(EZ)定位中的可行性和准确性.系统采用同一套电极,实现阻抗与EEG信号的同位、同时、同通道采集;通过"硬件低通+软件梳状"双域协同策略消除设备间互扰,确保精准采集信号.对 20 只健康成年雄性SD大鼠的测试结果表明,EIT定位的EZ质心与EEG地形图质心平均偏差仅 0.13 mm,平均相对误差为 6.37%,且该区域经组织学证实存在典型癫痫损伤特征,表明EIT具有精准定位EZ的可行性.本研究可为难治性癫痫EZ的精准定位提供新的思路,对提升癫痫救治率意义重大.
Regarding the problem for precise localization of refractory epileptic nidus,we developed an electrical impedance tomo-graphy(EIT)and electroencephalogram(EEG)synchronous detection system to verify the feasibility and accuracy of EIT in the localiza-tion of epileptogenic zone(EZ).The system employed the same set of electrodes to achieve simultaneous,synchronous and co-channel acquisition of impedance and EEG signals.The dual-domain collaborative strategy of"hardware low-pass+software comb"was used to eliminate mutual interference between devices,and ensure the accuracy of signal acquisition.The test results on 20 healthy adult male SD rats showed that the average deviation between EIT-localized and EEG-topography centroids was 0.13 mm,with a 6.37%rel-ative error.Moreover,the area was confirmed by histopathology to have typical features of epileptic lesions,indicating that EIT has the feasibility of accurately locating EZ.The research can offer a new method for precise EZ localization and significance for improving the success rate of epilepsy treatment.
朱文静;吴欣雨;杨敬荣;陈诚;吴冠;杨方;王蕾
西北工业大学 医学研究院,西安 710072西北工业大学 医学研究院,西安 710072西北工业大学 医学研究院,西安 710072杭州永川科技有限公司,杭州 310051杭州永川科技有限公司,杭州 310051空军军医大学西京医院 神经内科,西安 710032西北工业大学 医学研究院,西安 710072
医药卫生
电阻抗断层成像脑电图同步系统致痫灶定位滤波
Electrical impedance tomographyElectroencephalogramSynchronous detection systemEpileptogenic zone localiza-tionFilter
《生物医学工程研究》 2026 (1)
7-14,8
陕西省重点研发计划(2024SF-YBXM-451)西京医院医务人员培养交叉融合专项(XJZT24JC29).
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