基于迁移学习的癫痫脑电时空预测模型研究OA
Epilepsy electroencephalogram spatio-temporal prediction model based on transfer learning
针对现有癫痫脑电(EEG)预测模型跨被试时泛化性与鲁棒性不足的问题,本研究结合信号分析及深度学习技术,提出了一种基于迁移学习的多尺度癫痫EEG时空预测模型(TLEP-MST).首先,将原始数据通过独立成分分析(ICA)去除伪迹,并采用时间提取模块和小波卷积层提取EEG信号中的时频信息;其次,通过自适应注意力机制对时频信息进行多通道权重分配,获得EEG信号空间特征;最后,融合迁移学习方法,减少源域与目标域的数据分布差异,提高模型泛化性能.该模型在公用数据集CHB-MIT上进行了实验,在交叉验证中,模型准确率、特异性和误报率分别为91.88%、96.49%和0.0369/h;在患者特异性实验中,引入迁移学习后,模型的特异性从 67.04%提升到 85.06%,误报率从 0.4194/h降低到 0.3485/h.本研究在预测跨被试癫痫EEG方面具有重要价值.
To address the deficiencies in cross-subject generalizability and robustness of existing epileptic electroencephalogram(EEG)prediction models,we proposed a transfer learning-based epileptic prediction model with multi-scale spatio-temporal features(TLEP-MST)by integrating signal analysis and deep learning technology.Firstly,the raw data was analyzed through independent com-ponent analysis(ICA)to remove artifacts,and the temporal feature extraction module and wavelet convolutional layer were used to ex-tract the time-frequency information in the EEG signals.Then,the adaptive attention mechanism was applied to perform multi-channel weight assignment of the time-frequency information,and obtain spatial features of the EEG signals.Finally,transfer learning was in-corporated to reduce data distribution discrepancies between source and target domains,enhancing the model generalization perform-ance.The model was experimented on the public dataset CHB-MIT.In the cross-validation,the accuracy rate,specificity and false positive rate of the model was 91.88%,96.49%and 0.0369/h,respectively.In patient-specific experiments,the specificity improved from 67.04%to 85.06%,and the false positive rate decreased from 0.4194/h to 0.3485/h after introducing transfer learning.This re-search is of great value in predicting the EEG of epilepsy across subjects.
郑凯哲;唐诗诗;刘一聪;练伟;胡珊;许晓伟;周毅
中山大学 中山医学院,广州 510080中山大学 中山医学院,广州 510080中山大学附属第一医院,广州 510080中山大学 中山医学院,广州 510080中山大学 中山医学院,广州 510080中山大学附属第七医院,深圳 518000中山大学 中山医学院,广州 510080
医药卫生
癫痫预测深度学习时频分析迁移学习脑电信号
Epilepsy predictionDeep learningTime-frequency analysisTransfer learningElectroencephalogram signal
《生物医学工程研究》 2026 (1)
1-6,6
国家重点研发计划(2022YFC3601600)广东省自然科学基金项目(2024A1515011989).
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