巨噬细胞在缺血再灌注损伤和再生中的机制研究进展OA
Advances in research on the mechanisms of macrophages in ischemia-reperfusion injury and regeneration
缺血再灌注损伤是一个极其复杂的病理生理过程,广泛发生于器官移植、心肌梗死、卒中等过程.巨噬细胞作为免疫系统核心,在缺血再灌注后损伤和再生中起着至关重要的作用.经典激活的M1型巨噬细胞介导早期炎症风暴与组织损伤,而替代激活的M2型巨噬细胞则主导后期的炎症消退、组织修复与再生.巨噬细胞表型之间的动态平衡对于缺血再灌注损伤的结局十分重要.本文综述了巨噬细胞在缺血再灌注损伤和再生中的作用,包括巨噬细胞在缺血再灌注损伤中的双重角色、调控巨噬细胞动态极化的复杂网络.此外,本文重点评述了缺血再灌注损伤中靶向巨噬细胞的多种潜在治疗策略,旨在为缺血再灌注损伤和再生的相关研究提供参考.
Ischemia reperfusion injury is an extremely complex pathophysiological process that occurs widely in organ transplantation,myocardial infarction,stroke and other procedures.Macrophages,as central players in the immune system,has a crucial role in injury regeneration following ischemia-reperfusion.Classically ac-tivated M1 macrophages mediate the early inflammatory storm and tissue damage,while alternatively activat-ed M2 macrophages dominate the later stages of inflammation resolution,tissue repair and regeneration.The dynamic balance between macrophage phenotypes is critical for the outcome of ischemia-reperfusion injury.This review summarized the role of macrophages in ischemia-reperfusion injury and regeneration,covering their dual roles in ischemia-reperfusion injury and in the complex networks regulating their dynamic polariza-tion.Furthermore,the review highlighted various potential therapeutic strategies targeting macrophages in ischemia-reperfusion injury,aiming to provide insights for research related to ischemia-reperfusion injury and regeneration.
陈元明;武子硕;徐骁;鲁迪
浙江大学 医学院,浙江 杭州 310058杭州医学院 基础医学与法医学院,浙江 杭州 311300浙江大学 医学院,浙江 杭州 310058||杭州医学院 临床医学院,浙江 杭州 311300浙江大学 医学院,浙江 杭州 310058||杭州医学院 临床医学院,浙江 杭州 311300
医药卫生
巨噬细胞缺血再灌注损伤再生免疫调控代谢重编程细胞疗法
macrophagesischemia reperfusion injuryregenerationimmunoregulationmetabolic reprogram-mingcell therapy
《兰州大学学报（医学版）》 2026 (2)
1-7,7
国家科技重大专项(2024ZD0529000)
评论