外阴阴道念珠菌病的阴道给药新剂型研究进展OA

Vulvovaginal candidiasis(VVC)has a high incidence rate,and vaginal administra-tion is one of the main routes for its treatment.In recent years,there have been some advances in vaginal drug formulations.Among them,vaginal mucoadhesive gels can extend the retention time in the vagina;vaginal thermosensitive gels are easy to apply and dispense;vaginal films are small in volume,simple to prepare,and possess strong mucosal adhesion;vaginal sponges with dense voids have a large drug-loading capacity and can also achieve the purpose of targeted drug delivery through rational design;vaginal microspheres have high bioavailability,can improve drug solubili-ty,and enhance patient compliance;liquid crystal pre-formulations can reduce drug irritation and can also perform sustained and controlled drug release.These novel vaginal drug formulations can be used not only alone to exert therapeutic advantages but also in combination with existing tech-nologies,such as tablets and gels,to prepare composite formulations.This article will review the research progress of these new formulations that are being actively studied in the field of VVC treatment,aiming to provide a reference for the development of new vaginal formulations for VVC therapy.