神经梅毒血脑屏障破坏机制与诊断标志物的研究进展OA

Treponema pallidum is capable of invading the central nervous system,thereby cau-sing neurosyphilis.The pathogenesis of neurosyphilis is closely related to the ability of T.pallidum to penetrate the blood-brain barrier.The clinical manifestations of neurosyphilis are diverse and of-ten lack specificity,which poses challenges for early diagnosis.Both domestic and international guidelines for the diagnosis of neurosyphilis indicate that diagnosis should be based on a compre-hensive assessment of epidemiological history,clinical manifestations,and laboratory test results.This article systematically reviews recent domestic and international literature on neurosyphilis,an-alyzes the cellular and molecular mechanisms underlying blood-brain barrier disruption by T.palli-dum,and summarizes the diagnostic value of differential cerebrospinal fluid metabolites,chemo-kines,proteins,and serum biomarkers,with the aim of providing references for the diagnosis of neurosyphilis.