不同方式注射透明质酸治疗眶下区凹陷的安全性和有效性研究OA

Objective To compare the safety and efficacy of three different hyaluronic acid(HA)injection techniques for treating infraorbital hollowing.Methods A total of 80 eligible participants were enrolled and randomly assigned to three groups:sharp-needle group(n=27),blunt cannula single-plane group(n=26),and blunt cannula multi-plane group(n=27).All participants received commercially available cross-linked HA injections and were followed up at weeks 8,24,48,and 96.Efficacy was assessed using the Infraorbital Hollow Severity Scale(IOHSS)and Global Aesthetic Improvement Scale(GAIS).Injection volume,incidence of ad-verse events,and patient satisfaction were also evaluated.Results By week 96,the response rates(≥1-point improvement in IOHSS)were 77.3％in the sharp-needle group,47.6％in the single-plane blunt-needle group,and 87.0％in the multi-plane blunt-needle group,with a statis-tically significant difference among the groups(x2=8.86,P=0.012).GAIS scores assessed by investigators showed an improvement rate of 78.3％in the multi-plane group.The proportion of patients reporting being"very satisfied"(56.5％)was also significantly higher in this group(x2=6.38,P=0.041).Adverse event rates were similar across groups(x2=1.13,P=0.862),with mild bruising,erythema,and tenderness being the most common.No serious adverse events were reported.Total HA usage per participant did not differ significantly among the groups(F=0.12,P=0.886).Conclusions All three injection techniques are safe and effective for improving in-fraorbital hollowing.The use of a blunt needle for multi-plane injections shows a more stable trend in therapeutic efficacy and has advantages in terms of subjective satisfaction among the subjects.