重庆地区2017-2024年1 578例儿童化妆品不良反应临床特征分析OA

Objective To reveal the clinical characteristics of cosmetic adverse reactions(CARs)and relevant information in a pediatric population regarding pathogenic cosmetics in Chongqing from 2017 to 2024.This study aimed to provide characteristics of CARs in the pediatric population and to serve as an early warning and objective risk assessment tool for CARs in this de-mographic.Methods We extracted data from the Chongqing Drug Administration's cosmetic ad-verse events reporting system from 2017 to 2024 and screened the information of individuals under the age of 18 years for analysis.Results A total of 1,578 cases were reported,of which 1,165 were girls(73.83％)and 413 were boys(26.17％).Among these cases,289(18.31％)were caused by children's cosmetics.The most frequently reported clinical sign was erythema(73.95％),followed by papules(39.67％)and scales(15.59％).Itching,burning,and tightness were the most prominent symptoms,accounting for 82.83％,35.17％,and 24.90％,respectively.The face was the most vulnerable site for lesions,accounting for 78.45％of all are-as,followed by the cheeks(31.18％),forehead(24.08％),and perioral/lips(13.75％).Girls had a significantly higher rate of facial damage than boys,while boys had a significantly higher rate of scalp damage than girls.Contact dermatitis(89.35％)was the most common diag-nosis of CARs,followed by acne(2.60％)and cheilitis(1.90％).The majority of CARs were reported to be due to creams,ointments,lotions,and toners(48.32％),followed by facial masks(8.18％),cleaning products(7.41％),and hair products(6.89％).Sunscreen products(6.64％)and whitening products(3.93％)were frequently reported among cosmetics with spe-cial functions.There were 15 cases with a history of cosmetic allergy,and 1 case each of a history of adverse reactions to food and medication.Conclusions From 2017 to 2024,the incidence of adverse reactions to cosmetics among children in the Chongqing region has been increasing year by year,with a higher occurrence in girls than boys.The head,face,and neck are the most affected areas,and contact dermatitis is the most common type of reaction.Acne-like lesions gradually ap-pear after puberty,and ordinary cosmetics are more likely to cause adverse reactions.Pediatri-cians and dermatologists should actively submit reports of cosmetic adverse reaction events and en-courage consumers to report when products have a negative impact on children's health.