150例泛发性脓疱型银屑病患者的临床表征回顾性分析OA

Objective To analyze the clinical characteristics of patients with generalized pus-tular psoriasis,we aimed to provide stronger theoretical support for the health management of GPP patients.Methods A retrospective analysis was conducted on the data of 150 patients with gener-alized pustular psoriasis(GPP)who visited the Dermatology Hospital,Southern Medical Universi-ty from July 2017 to July 2023.The patients were grouped according to age of onset,gender,and whether GPP was accompanied by psoriasis vulgaris(PV).The analysis aimed to explore the differences in clinical characteristics among different groups of GPP patients,including the season of onset and triggers,recurrence frequency,comorbidities,and treatment outcomes.Results A total of 150 patients with generalized pustular psoriasis(GPP),with a mean onset age of 32.83±21.65 years,were included in the analysis.The mean age of onset was significantly lower in pa-tients with GPP alone than in those with both GPP and psoriasis vulgaris(PV)(28.30±19.27 vs.40.87±23.43 years,t=-3.51,P＜0.05).The proportion of patients who were overweight was significantly higher in those with an onset age of ≥18 years(39.4％)compared to those with an onset age of＜18 years(17.4％)(x2=7.04,P＜0.05).The mean waist circumference of all adult male and female patients met the criteria for abdominal obesity.GPP had a predilection for onset in spring and summer.The probability of onset in spring and summer was significantly higher in patients with GPP alone(70.3％)than in those with GPP and PV(50.0％)(x2=5.45,P＜0.05).Improper treatment was identified as the primary triggering factor for GPP.The proportion of patients with improper treatment as a triggering factor was significantly higher in the GPP+PV group than in the GPP alone group(71.7％vs.5.2％,x2=74.22,P＜0.001).Re-garding triggering factors for relapse,improper treatment was the most common in patients with an onset age of＞18 years(39.5％),while upper respiratory tract infections were predominant in patients with an onset age of ≤18 years(40.0％).In female patients,some relapses were associ-ated with special physiological states such as pregnancy and menstruation.The recurrence rate was significantly higher in patients with an onset age of≤18 years than in those＞18 years(91.3％vs.71.7％,x2=7.39,P＜0.05).Females had a significantly higher probability of experiencing 3 to 4 relapses within a year than males(x2=4.20,P＜0.05).Patients with GPP alone were more prone to recurrence,with significantly higher probabilities of experiencing 1 to 2 relapses and 1 to 4 relapses within one year compared to the GPP+PV group(all P＜0.05).Males had a sig-nificantly higher probability of nail involvement and moderate fever than females(both P＜0.05)but a significantly lower probability of high fever(x2=3.90,P＜0.05).The probability of joint involvement was significantly higher in the GPP+PV group than in the GPP alone group(x 2=7.55,P＜0.05).Furthermore,hypertension was more commonly associated with GPP+PV than with GPP alone(x2=5.79,P＜0.05).Acitretin was the most commonly used drug.Patients re-ceiving combination therapy with immunosuppressants had the longest hospital stay(12.57±5.47 days),while those treated with biological agents alone had the shortest hospital stay(5.61±2.33 days)(P＜0.05).Conclusions Factors such as gender,age,and comorbidity with PV signifi-cantly impact the clinical presentation and treatment response of GPP.Early identification of trig-gering factors,precise subgroup-based interventions,and monitoring of biomarkers are crucial strategies to improve the clinical outcomes of GPP patients.