银屑病生物制剂长期维持治疗的专家指导意见OA

This expert recommendation addresses key challenges encountered in the long-term maintenance treatment of psoriasis with biologic agents.Based on current evidence from evidence-based medicine and accumulated clinical experience,experts from the Psoriasis Quality Control Group of Guangdong Provincial Quality Control Center systematically outline the therapeutic goals,principles,and strategies for long-term biologic maintenance therapy in psoriasis.The recommen-dations emphasize sustained and stable disease control as the primary objective.After achieving the expected therapeutic response during the induction phase,treatment strategies should be dy-namically individualized according to relapse risk assessment.Potential approaches include main-taining the initially effective regimen,optimizing treatment,stepwise dose reduction or discontinu-ation,and switching therapy when necessary.The recommendations also highlight the importance of long-term follow-up and standardized monitoring.Additionally,lifestyle factors,including body weight management,dietary optimization,smoking cessation,alcohol restriction,and regular physical activity,are incorporated into long-term outcome optimization.Overall,these recommen-dations aim to balance efficacy,safety,and long-term patient management needs,providing a structured decision-making framework for clinical practice.