精神分裂症Galectin-3与BDNF和S100B表达及与认知功能关系OA
Expression levels of Galectin-3,brain-derived neurotrophic factor,and S100 calcium-binding protein B and their association with cogni-tive function in patients with schizophrenia
目的 探讨精神分裂症病人外周血中半乳糖凝集素-3(Galectin-3)、脑源性神经营养因子(BDNF)及S100钙结合蛋白B(S100B)的表达水平,并分析其与临床症状及认知功能障碍的相关性.方法 2023年1月—2024年12月,选择驻马店市第二人民医院收治的121例精神分裂症病人为观察组,并纳入同期性别、年龄匹配的健康体检者100例为对照组.依据蒙特利尔认知评估量表(MoCA)或MATRICS共识认知成套测验(MCCB)评分,将观察组进一步分为认知正常组与认知障碍组.检测各组血清Galectin-3、BDNF及S100B水平;运用Pearson相关分析法探讨上述指标与阳性和阴性症状量表(PANSS)评分及认知功能的相关性;通过受试者工作特征(ROC)曲线下面积(AUC)分析其预测认知障碍的临床效能.结果 观察组及认知障碍组的血清Galectin-3和S100B表达显著高于对照组及认知正常组,而BDNF表达则显著低于对照组及认知正常组,差异均有显著性(t=4.388～19.114,P均＜0.05).认知障碍组的PANSS总分显著高于认知正常组,而MCCB认知综合得分显著低于认知正常组(t=12.172、14.466,P均＜0.05).相关性分析显示,Galectin-3和S100B表达均与PANSS评分呈正相关,而与MCCB评分呈负相关(r=-0.523～0.385,P均＜0.05);BDNF表达与PANSS评分呈负相关,而与MCCB评分呈正相关(r=-0.319、0.313,P均＜0.05).血清Galectin-3、BDNF和S100B单独及其联合对认知功能障碍均有一定预测价值,但以三者联合预测的效能最高(AUC=0.874,95％CI=0.811～0.938,P＜0.05),灵敏度为81.3％,特异度为82.2％.结论 精神分裂症病人存在Galectin-3、S100B升高及BDNF降低的生物学改变,且与认知功能损害密切相关.三者联合检测可作为评估精神分裂症病人认知功能障碍的有效生物标志物.
Objective To investigate the expression levels of Galectin-3,brain-derived neurotrophic factor(BDNF),and S100 calcium-binding protein B(S100B)in the peripheral blood of patients with schizophrenia and their association with cognitive function.Methods A total of 121 patients with schizophrenia who were admitted to Zhumadian Second People's Hospital from January 2023 to December 2024 were enrolled as observation group,and 100 individuals matched for sex and age during the same period of time were enrolled as control group.According to the score of Montreal Cognitive Assessment(MoCA)or MATRICS Consensus Cognitive Battery(MCCB),the observation group was further divided into cognitively normal group and cognitive im-pairment group.The serum levels of Galectin-3,BDNF,and S100B were measured;a Pearson correlation analysis was used to in-vestigate the correlation of the above indicators with Positive and Negative Syndrome Scale(PANSS)score and cognitive function;the receiver operating characteristic(ROC)curve and the area under the ROC curve(AUC)were used to assess the value of these markers in predicting cognitive impairment.Results Compared with the control group and the cognitively normal group,the observation group and the cognitive impairment group had significantly higher expression levels of Galectin-3 and S100B and a sig-nificantly lower expression level of BDNF in serum(t=4.388-19.114,all P＜0.05).Compared with the cognitively normal group,the cognitive impairment group had significantly higher total score and scores on each subscale of PANSS and a significantly lower MCCB comprehensive cognitive score(t=12.172,14.466;both P＜0.05).The correlation analysis showed that the expression levels of Galectin-3 and S100B were positively correlated with PANSS score and were negatively correlated with MCCB score(r=—0.523 to 0.385,all P＜0.05);in contrast,the expression level of BDNF was negatively correlated with PANSS score and was positively correlated with MCCB score(r=—0.319,0.313;both P＜0.05).Serum Galectin-3,BDNF,and S100B alone and in combination had a certain value in predicting cognitive impairment,and the combination of the three markers had the highest pre-dictive efficacy,withan AUC of 0.874(95％CI=0.811-0.938,P＜0.05),a sensitivity of 81.3％,and a specificity of 82.2％.Conclusion Patients with schizophrenia have increases in the serum levels of Galectin-3 and S100B and a reduction in the serum level of BDNF,which are closely associated with cognitive impairment.Combined measurement of the three biomarkers can be used to predict cognitive impairment in patients with schizophrenia.
林彬;孙连峰;赵云东
驻马店市第二人民医院心理六科,河南驻马店 463000驻马店市第二人民医院心理六科,河南驻马店 463000驻马店市第二人民医院心理六科,河南驻马店 463000
医药卫生
精神分裂症半乳糖凝集素3脑源性神经营养因子S100钙结合蛋白B认知功能障碍数据相关性预测
schizophreniagalectin 3brain-derived neurotrophic factorS100 calcium binding protein Bcognitive dysfunc-tioncorrelation of dataforecasting
《青岛大学学报（医学版）》 2026 (1)
160-165,6
河南省医学科技攻关计划项目(232102-310033)
评论