SII、D-D对乳腺良恶性肿块的鉴别价值分析OA

Objective To analyze the value of systemic immune inflammation index(SII)in peripheral blood combined with D-dimer(D-D)in plasma in the differential diagnosis of benign and malignant breast masses.Methods A total of 408 patients with breast masses who were treated in Huidong County Maternal and Child Health Hospital from January 2020 to December 2024 were selected as the research objects.Accord-ing to the Results of postoperative pathological examination,they were divided into benign breast disease group(266 cases)and breast cancer group(142 cases).According to molecular typing,the patients were di-vided into triple negative breast cancer group(23 cases)and Luminal A+Luminal B breast cancer group(119 cases).Baseline data of all patients were collected.Multivariate Logistic regression was used to analyze the in-fluencing factors of malignant breast tumors and triple-negative breast cancer.The receiver operating charac-teristic(ROC)curve was drawn to analyze the value of SII,D-D alone and their combination in the differentia-tion of benign and malignant breast masses,and the value of SII,D-D alone and their combination in the evalu-ation of triple-negative breast cancer.Results The preoperative SII and D-D levels in the breast cancer group were higher than those in the benign breast disease group,and the differences were statistically significant(P<0.05).The preoperative SII and D-D levels in the triple-negative breast cancer group were higher than those in the Luminal A+Luminal B breast cancer group,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that the increase of preoperative SII and D-D level were both risk factors for malignant breast masses(P<0.05).Preoperative SII and elevated D-D level were both risk factors for triple-negative breast cancer(P<0.05).The results of ROC curve analysis showed that the area under the curve(AUC)of SII,D-D alone,and their combination in differentiating benign and malig-nant breast masses were 0.771,0.786,and 0.868,respectively.The AUC of the combination of the two in dif-ferentiating benign and malignant breast masses was greater than that of SII or D-D alone(P<0.05).The AUC of SII,D-D,and the combination of the two in evaluating triple negative breast cancer were 0.749,0.748,and 0.828,respectively.The AUC of the combination of the two in evaluating triple negative breast cancer was greater than that of SII or D-D alone(P<0.05).Conclusion SII combined with D-D detection can effectively distinguish benign and malignant breast masses and evaluate the occurrence of triple-negative breast cancer,which can provide reference for the early evaluation of breast cancer.