针灸联合骨松宝颗粒治疗女性绝经后骨质疏松症的疗效及对血清骨代谢指标、IGF-1水平的影响OA

Objective To investigate the clinical efficacy of acupuncture combined with Gusongbao granule in the treatment of women with postmenopausal osteoporosis(PMOP)and its effect on serum bone metabo-lism indexes and insulin-like growth factor-1(IGF-1)levels.Methods A total of 105 postmenopausal women with PMOP admitted to Qidong People's Hospital from January 1,2022 to June 30,2024 were selected as the research objects,and all patients were divided into control group(52 cases)and observation group(53 cases)by random number table method.Both groups received basic treatment,and the control group was treated with Gusongbao granule in addition to basic treatment.The observation group was treated with acupuncture and moxibustion on the basis of the control group.The clinical efficacy,bone metabolism indexes[osteocalcin(BGP),β-collagen degradation products(β-CTX),alkaline phosphatase(ALP)],bone mineral density(BMD),visual analogue scale(VAS)score,IGF-1 level and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 98.11%,which was higher than 88.46%of the control group,and the difference was statistically significant(P<0.05).The levels of BGP and ALP in the two groups after treatment were higher than those before treatment,and the levels of BGP and ALP in the observation group after treatment were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of β-CTX in the two groups were lower than those before treatment,and the level of β-CTX in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).The BMD of L1-4 and femoral neck of the two groups after treatment were higher than those before treatment,and the BMD of L1-4 and femoral neck of the observation group after treatment were higher than those of the control group,and the differences were statistically significant(P<0.05).The VAS scores of the two groups after treatment were lower than those before treatment,and the VAS score of the observation group after treatment was lower than that of the con-trol group,and the differences were statistically significant(P<0.05).The IGF-1 levels of the two groups af-ter treatment were higher than those before treatment,and the IGF-1 level of the observation group after treatment was higher than that of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Acupuncture combined with Gusongbao granule is effective in the treatment of fe-male PMOP after menopause,which can significantly regulate bone metabolism,increase bone mineral densi-ty,relieve pain and improve serum IGF-1 level,and has good safety.