A comprehensive proteomic analysis uncovers novel molecular subtypes of gastric signet ring cell carcinoma:Identification of potential prognostic biomarkers and therapeutic targetsOA
A comprehensive proteomic analysis uncovers novel molecular subtypes of gastric signet ring cell carcinoma:Identification of potential prognostic biomarkers and therapeutic targets
Zhiyuan Jin;Zhiyuan Xu;Yian Du;Xiaoqing Guan;Guangzhao Pan;Sichao Tian;Juan Li;Ruiwen Zhang;Jiang-Jiang Qin;Xiangdong Cheng;Li Yuan;Yubo Ma;Zu Ye;Zhao Zhang;Yi Wang;Can Hu;Jinyun Dong;Xinuo Zhang
School of Life Sciences,Tianjin University,Tianjin 300000,China||Zhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou,Zhejiang 310022,ChinaZhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou,Zhejiang 310022,China||Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer,Zhejiang Cancer Hospital,Hangzhou,Zhejiang 310022,China||Key Laboratory of Prevention,Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province,Hangzhou,Zhejiang 310022,ChinaZhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou,Zhejiang 310022,China||Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer,Zhejiang Cancer Hospital,Hangzhou,Zhejiang 310022,China||Key Laboratory of Prevention,Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province,Hangzhou,Zhejiang 310022,ChinaZhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou,Zhejiang 310022,ChinaZhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou,Zhejiang 310022,ChinaInstitute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193,ChinaZhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou,Zhejiang 310022,ChinaDepartment of Pharmacological and Pharmaceutical Sciences,College of Pharmacy,University of Houston,Houston,TX 77204,USAZhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou,Zhejiang 310022,China||Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer,Zhejiang Cancer Hospital,Hangzhou,Zhejiang 310022,China||Key Laboratory of Prevention,Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province,Hangzhou,Zhejiang 310022,ChinaZhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou,Zhejiang 310022,China||Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer,Zhejiang Cancer Hospital,Hangzhou,Zhejiang 310022,China||Key Laboratory of Prevention,Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province,Hangzhou,Zhejiang 310022,ChinaZhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou,Zhejiang 310022,China||Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer,Zhejiang Cancer Hospital,Hangzhou,Zhejiang 310022,China||Key Laboratory of Prevention,Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province,Hangzhou,Zhejiang 310022,ChinaZhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou,Zhejiang 310022,ChinaZhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou,Zhejiang 310022,ChinaMOE Key Laboratory of Metabolism and Molecular Medicine,Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Fudan University,Shanghai 200032,ChinaZhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou,Zhejiang 310022,ChinaZhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou,Zhejiang 310022,ChinaZhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou,Zhejiang 310022,ChinaZhejiang Cancer Hospital,Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou,Zhejiang 310022,China
Drug targetGastric signet ring cell carcinomaMolecular subtypesPrognostic markersProteomics
Drug targetGastric signet ring cell carcinomaMolecular subtypesPrognostic markersProteomics
《基因与疾病（英文）》 2026 (1)
569-585,17
This work was supported by the National Key Research and Development Program of China(No.2021YFA0910100,2021YFA0910101),the Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer(China)(No.JBZX-202006),the Innovation Team and Talents Cultivation Pro-gram of the National Administration of Traditional Chinese Medicine(China)(No.ZYYCXTD-C-202208),the Medical Science and Technology Project of Zhejiang Province,China(No.WKJ-ZJ-2202,WKJ-ZJ-2104),the National Natural Science Foundation of China(No.82074245,81973634,82204828),the Natural Science Foundation of Zhejiang Province,China(No.QKHM25H3103,LHDMY22H160008),the Zhejiang Leading Innovation and Entrepreneurship Team(China)(No.2022R01006),the Pioneer R&D Program of Zhejiang,China(No.2024SDYXS0003,2023SDYXS0001),and the Program of Zhejiang Provincial TCM Sci-Tech Plan(China)(No.GZY-ZJ-KJ-24064).
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