Transcriptional rewiring by enhancer methylation in CBFA2T3-GLIS2-driven pediatric acute megakaryoblastic leukemiaOA
Transcriptional rewiring by enhancer methylation in CBFA2T3-GLIS2-driven pediatric acute megakaryoblastic leukemia
Samrat Roy Choudhury;Akhilesh Kaushal;Pritam Biswas;Cory Padilla;Jay F.Sarthy;Arundhati Chavan;Giselle Almeida Gonzalez;Soheil Meshinchi;Jason E.Farrar
Pediatric Hematology-Oncology,Department of Pediatrics,Arkansas Children's Research Institute,University of Arkansas for Medical Sciences,Little Rock,AR 72202,USAPediatric Hematology-Oncology,Department of Pediatrics,Arkansas Children's Research Institute,University of Arkansas for Medical Sciences,Little Rock,AR 72202,USAPediatric Hematology-Oncology,Department of Pediatrics,Arkansas Children's Research Institute,University of Arkansas for Medical Sciences,Little Rock,AR 72202,USACantata Bio,Scotts Valley,CA 95066,USASeattle Children's Research Institute,Seattle,WA 98105,USAPediatric Hematology-Oncology,Department of Pediatrics,Arkansas Children's Research Institute,University of Arkansas for Medical Sciences,Little Rock,AR 72202,USAPediatric Hematology-Oncology,Department of Pediatrics,Arkansas Children's Research Institute,University of Arkansas for Medical Sciences,Little Rock,AR 72202,USATranslational Science and Therapeutics Division,Fred Hutchinson Cancer Center,Seattle,WA 98109,USAPediatric Hematology-Oncology,Department of Pediatrics,Arkansas Children's Research Institute,University of Arkansas for Medical Sciences,Little Rock,AR 72202,USA
Acute megakaryo-blastic leukemiaAcute myeloid leukemiaCBFA2T3-GLIS2cis-regulatory elementsDNA methylationEnhancer
Acute megakaryo-blastic leukemiaAcute myeloid leukemiaCBFA2T3-GLIS2cis-regulatory elementsDNA methylationEnhancer
《基因与疾病（英文）》 2026 (1)
404-419,16
This study is supported by the US Department of Defense RCRP Program(No.HT9425-24-1-0932),the National Insti-tute of General Medical Sciences(USA)(No.2P20GM121293),and the Marion B.Lyon New Scientist Development Award of Arkansas Children's Research Insti-tute(USA)(No.LYON5069,awarded to S.R.C.).Partial support is also provided by start-up funds from the Uni-versity of Arkansas for Medical Sciences and Arkansas Bioscience Institute(USA)(No.ABIRC4426 to S.R.C.).
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