A systematic CRISPR screen reveals an NBL1-mediated Jak/Stat3 crosstalk to promote ovarian cancer metastasisOA

作者：Yue Qi;Wenwen Zhang;Xinyu Li;Yi Shi;Pengpeng Qu

作者单位：Clinical School of Obstetrics and Gynecology Center,Tianjin Medical University,Tianjin 300100,China||Department of Gynecological Oncology,Tianjin Central Hospital of Gynecology Obstetrics,Tianjin 300100,ChinaDepartment of Gynecological Oncology,Tianjin Central Hospital of Gynecology Obstetrics,Tianjin 300100,ChinaClinical School of Obstetrics and Gynecology Center,Tianjin Medical University,Tianjin 300100,China||Department of Gynecological Oncology,Tianjin Central Hospital of Gynecology Obstetrics,Tianjin 300100,ChinaThe School of Medicine,Nankai University,Tianjin 300071,ChinaClinical School of Obstetrics and Gynecology Center,Tianjin Medical University,Tianjin 300100,China||Department of Gynecological Oncology,Tianjin Central Hospital of Gynecology Obstetrics,Tianjin 300100,China||The School of Medicine,Nankai University,Tianjin 300071,China

中文关键词：CRISPR/Cas9 screenEMTJak/stat3NBL1Ovarian cancer metastasis

英文关键词：CRISPR/Cas9 screenEMTJak/stat3NBL1Ovarian cancer metastasis

刊名：《基因与疾病（英文）》 2026 (1)

页码/页数：390-403,14

基金：The study was funded by Tianjin Science and Technology Project(No.24JCYBJC01650)and the Tianjin Education Commission Planning Project(No.2023YXZD06).

DOI：10.1016/j.gendis.2025.101740