绵羊FecB基因的分布、检测方法及应用研究进展OA

Litter size is one of the core economic traits for evaluating reproductive performance of sheep and plays a decisive role in determining the reproductive efficiency and breeding economic benefits of sheep.The FecB gene(BMPR-IB gene),as a major gene regulating the prolificacy trait in sheep,was identified early,found a wide distribution in sheep breeds,and has been extensively reported regarding its regulatory mechanisms,making it an important molecular marker in the genetic improvement of sheep reproductive traits.Among alleles of FecB Gene,the B allele generated by the c.746A＞G mutation is the functional mutation that leads to high fecundity in multiporous lambing sheep breeds such as Hu sheep and Small Tail Han sheep.Different genotypes at this locus exert significant additive and dominant effects on ovulation rate and litter size in sheep,for instance,the litter size of sheep with BB and B+genotypes is significantly higher than that of the++genotype.This paper reviews the population distribution,genotyping methods and applications of the FecB gene,aiming to provide a reference for the precise improvement of sheep reproductive performance and the breeding of high-yield breeds or strains.