伴意识障碍颞叶癫痫的PET代谢脑网络及枢纽重构OA

Objective To investigate the alterations in graph-theoretical properties and Hub nodes of metabolic brain networks in patients with temporal lobe epilepsy with impaired awareness seizures(TLE-IAS),and explore the mechanisms of its characteristic metabolic network reorganization.Methods A total of 193 patients(TLE-IAS group)with TLE-IAS who underwent 18F-FDG PET/CT at the Department of Nuclear Medicine,the Second Hospital of Lanzhou University between January 2018 and January 2025 were retrospectively included,along with 193 controls(control group)without central nervous system disorders.At the group level,Pearson correlation coefficients between each brain region pair were calculated for both groups to construct PET metabolic brain networks for the TLE-IAS group and the control group.Non-parametric permutation testing with 1 000 iterations was then applied to compare group differences in graph-theoretical metrics and Hub node distribution.Results Compared with the control group,globally weakened metabolic connectivity was exhibited in the TLE-IAS patient group.Graph-theoretical analysis revealed a significantly increased Lp and significantly decreased Cp and mean degree(P<0.05).However,Eg and Eloc showed no significant group differences after FDR correction.Thirteen Hub nodes were identified in the control group,compared to eight in the TLE-IAS group.Furthermore,a spatial reorganization of hubs was demonstrated in patients,characterized by a shift from the default mode network toward the limbic system and primary sensory cortices.Conclusion TLE-IAS patients exhibit widespread weakened metabolic connectivity,impaired network transmission efficiency and information processing capacity,alongside a reduced number of Hub nodes and their spatial reorganization.