儿童阻塞性睡眠呼吸暂停伴无症状分泌性中耳炎的治疗路径选择OA
Selection of treatment pathways for pediatric obstructive sleep apnea with asymptomatic otitis media with effusion
目的 探讨合并阻塞性睡眠呼吸暂停(OSA)的无症状分泌性中耳炎(OME)患儿的治疗策略,为临床提供治疗指导.方法 选取首都医科大学附属北京儿童医院耳鼻咽喉头颈外科2023年4月~2024年5月期间,在以儿童OSA为首诊且拟行手术治疗的病例中,筛查出无症状OME患儿74例(107耳)为研究对象,采用Excel随机数字排序分组法,分为A组27例(37耳)、B组26例(38耳)和C组21例(32耳),3组患儿均进行腺样体和(或)扁桃体切除术,其中A组未进行耳部干预、B组接受耳内镜下鼓膜切开术、C组接受耳内镜下鼓膜置管术.术后随访12个月,通过时间效应、组间效应及时间-组间交互效应的分析,对比各组患儿术前、术后不同随访时间节点的听力预后与临床疗效,各组的复发以及并发症情况.结果 (1)听力比较:术后1、3、6个月,手术干预后(B组、C组)听力阈值均低于观察组(A组)(P<0.05),且C组低于B组;术后12个月,3组间比较差异无统计学意义(P=0.585).3组间变化存在显著时间效应、组间效应及时间-组间交互效应(P<0.05),C组听力提升最早,B组次之,A组最晚.(2)临床疗效评估:术后1、3、6个月,3组患儿临床疗效比较差异均有统计学意义(P<0.001),其中治愈率C组>B组>A组(P<0.05);术后12个月时,3组患儿临床疗效比较差异无统计学意义(P>0.05).(3)复发情况:随访期间,3组患儿复发率无显著差异(χ2=1.846,P=0.643).(4)并发症情况:3组患儿并发症发生率无统计学差异(χ2=2.231,P=0.328).结论 对于OSA合并无症状OME的患儿,建议在进行OSA手术时,同期干预,在腺样体和(或)扁桃体切除术的同时,行鼓膜置管术后的临床疗效更优、听力阈值改善更快更显著.
OBJECTIVE To explore the treatment strategies for children with asymptomatic otitis media with effusion(OME)complicated by obstructive sleep apnea(OSA)and provide clinical treatment guidance.METHODS In this study,selected patients from the Department of Otolaryngology Head and Neck Surgery,Beijing Children's Hospital between April 2023 and May 2024,74 children(107 ears)with asymptomatic OME were screened out from cases initially diagnosed with pediatric OSA and scheduled for surgical treatment.They were randomly divided into three groups using the random number sorting method in Excel:Group A with 27 children(37 ears),Group B with 26 children(38 ears),and Group C with 21 children(32 ears).All children in the three groups underwent tonsillectomy and/or adenoidectomy.Among them,Group A did not receive ear intervention,Group B received myringotomy under otoscopy,and Group C received tympanostomy tube insertion under endoscopic.The children were followed up for 12 months after surgery.Through the analysis of time effect,between-group effect,and time-group interaction effect,we compared the hearing prognosis,clinical efficacy,recurrence,and complication status of children in each group at different follow-up time points before and after surgery.RESULTS 1.Hearing comparison:At 1,3,and 6 months after surgery,the hearing thresholds of the groups with otoscopic surgical intervention(Group B and Group C)were lower than those of the observation group(Group A)(P<0.05),and the hearing threshold of Group C was lower than that of Group B.At 12 months after surgery,there was no significant difference among the three groups(P=0.585).There were significant time effects,inter-group effects,and time-inter-group interaction effects among the three groups(P<0.05).The hearing improvement in Group C occurred the earliest,followed by Group B,and then Group A.2.Clinical efficacy evaluation:At 1,3,and 6 months after surgery,there were significant differences in clinical efficacy among the three groups of children(P<0.001).The cure rate was in the order of Group C>Group B>Group A(P<0.05).At 12 months after surgery,there was no significant difference in clinical efficacy among the three groups of children(P>0.05).3.Recurrence:During the follow-up period,there was no significant difference in the recurrence rate among the three groups of children(χ2=1.846,P=0.643).4.Complications:There was no significant difference in the incidence of complications among the three groups of children(χ2=2.231,P=0.328).CONCLUSION For pediatric patients with OSA combined with asymptomatic OME,synchronous intervention during OSA surgery is recommended.Tonsillectomy and/or Adenoidectomy combined with tympanostomy tube placement yields superior clinical efficacy,characterized by faster and more significant improvement in hearing thresholds.
张燕;徐浪;张杰
国家儿童医学中心,首都医科大学附属北京儿童医院耳鼻咽喉头颈外科,北京 100045||儿童耳鼻咽喉头颈外科疾病北京市重点实验室,北京 100045||绵阳市妇幼保健院,绵阳市儿童医院耳鼻咽喉科,四川 绵阳 621000国家儿童医学中心,首都医科大学附属北京儿童医院耳鼻咽喉头颈外科,北京 100045||儿童耳鼻咽喉头颈外科疾病北京市重点实验室,北京 100045国家儿童医学中心,首都医科大学附属北京儿童医院耳鼻咽喉头颈外科,北京 100045||儿童耳鼻咽喉头颈外科疾病北京市重点实验室,北京 100045||郑州大学附属儿童医院,河南省儿童医院郑州儿童医院耳鼻咽喉头颈外科,河南省儿童睡眠呼吸疾病早期筛查与精准诊疗工程研究中心,河南 郑州 450018
儿童睡眠呼吸暂停,阻塞性无症状分泌性中耳炎鼓膜置管术
ChildSleep Apnea,Obstructiveasymptomatic otitis media with effusiontympanostomy tube insertion
《中国耳鼻咽喉头颈外科》 2026 (1)
22-26,5
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