针灸治疗卵巢功能减退的研究进展OA

In recent years,the incidence of diminished ovarian reserve(DOR)has been increasing annually.While hormone replacement therapy(HRT)remains the primary clinical treatment,it is associated with significant side effects.Acupuncture,as an alternative therapy,has demonstrated potential in this regard.This article systematically reviews and analyzes clinical and mechanistic research literature from the past decade.It concludes that acupuncture can improve patients'hormone levels and ovarian reserve indicators,with the core acupoint selection primarily focusing on abdominal and lower-limb points such as Guanyuan(CV4)and Sanyinjiao(SP6).The main treatment methods include electroacupuncture and manual acupuncture,with treatment cycles typically exceeding three months.In terms of mechanisms,preliminary studies suggest that acupuncture may exert therapeutic effects by mitigating oxidative stress,suppressing inflammatory responses,and modulating multiple signaling pathways,including FSH/cAMP,PI3K/Akt,and Bcl-2/Caspase-3.However,current research still faces limitations,such as a lack of standardized clinical protocols,insufficient high-quality evidence,and inadequate exploration of mechanisms.Future studies should focus on conducting high-quality clinical research to optimize treatment protocols and employ multidisciplinary approaches to elucidate the mechanisms of action,thereby promoting the standardization and clinical application of acupuncture therapy.