中医药调控相关信号通路干预卒中后认知障碍的研究进展OA
Research Progress on the Regulation of Signaling Pathways Related to Traditional Chinese Medicine in the Intervention of Post-stroke Cognitive Impairment
卒中后认知障碍(Post-Stroke Cognitive Impairment,PSCI)是脑卒中常见并发症,发生率高且严重影响患者生活质量,其发病机制复杂,涉及神经元损伤、炎症反应与氧化应激等多种病理过程.目前针对该病缺乏特异性的治疗手段,现有治疗手段存在靶向性不足且副作用明显等问题.而中医药以其多成分、多靶点、整体调节的优势,在PSCI防治中展现出显著潜力.大量研究发现,PI3K/Akt、Wnt/β-catenin、NF-κB、NLRP3炎症小体、Nrf2/HO-1等相关信号通路在PSCI的防治中发挥重要作用.本文系统综述近5年中医药调控以上信号通路治疗PSCI的研究进展,以期为中医药治疗PSCI的临床转化应用提供参考.
Post-stroke cognitive impairment(PSCI)is a common complication of stroke,with a high incidence and severe impact on patients'quality of life.Its pathogenesis is complex and involves multiple pathological processes such as neuronal injury,inflammatory response,and oxidative stress.At present,there is a lack of specific therapeutic strategies for this disease,and the existing treatments are limited by insufficient targeting and obvious adverse reactions.Traditional Chinese medicine(TCM),with its characteristics of multi-component,multi-target and holistic regulation,has shown great potential in the prevention and treatment of PSCI.Many studies have confirmed that multiple signaling pathways,including PI3K/Akt,Wnt/β-catenin,NF-κB,NLRP3 inflammasome,and Nrf2/HO-1,play key roles in the occurrence and development of PSCI.This paper systematically reviews the research progress of TCM intervention on these signaling pathways in the treatment of PSCI in the past five years,so as to provide a reference for the clinical transformation and application of TCM in the management of PSCI.
徐瑾;周霞;吴春玲;纪孝伟
山东中医药大学,山东 济南 250014山东中医药大学第二附属医院,山东 济南 250001山东第一医科大学附属中心医院,山东 济南 250013山东中医药大学实验中心,山东 济南 250355
医药卫生
卒中后认知障碍中医药信号通路研究进展
post-stroke cognitive impairmenttraditional Chinese medicinesignaling pathwaysresearch progress
《中医康复》 2026 (4)
24-30,7
中华中医药学会委托项目(2021XS-001)
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