基于肾-髓-脑-骨轴探讨骨质疏松症的发病机制OA

Osteoporosis(OP)is a systemic bone metabolic disease characterized by decreased bone mass and de-struction of bone micro-structure.Its pathogenesis is complex and involves multi-system interactions.In recent years,increasing evidence suggests that a cross-organ regulatory network established between the central nervous system and the skeletal system through the"kidney-marrow-brain-bone"axis plays a crucial role in the pathogenesis of OP.This article aims to elucidate the regulatory mechanisms of the central nervous system on bone metabolism and the feed-back mechanisms of the skeletal system to the central nervous system from this emerging perspective of the"kidney-marrow-brain-bone"axis,comprehensively analyzing ancient Chinese medical texts,modern neuroscience research findings,and clinical data,and to explore new mechanisms of osteoporosis pathogenesis.