CKIP-1在肿瘤免疫微环境中的功能及其作用机制研究进展OA

Casein kinase 2-interacting protein-1(CKIP-1)is a multifunctional scaffold protein with a pleckstrin homology domain.Its dynamic subcellular localization enables dual roles in tumor progression,"promoting"or"suppressing"malignancy by regulating immune metabolism and signaling networks within the tumor immune microenvironment(TIME).This review synthesizes current knowledge on CKIP-1's structural characteristics and TIME regulatory mechanisms.We highlight that CKIP-1 inhibits macrophage M2 polarization,antagonizes Smurf1-mediated oncoprotein ubiquitination,and modulates key pathways,including TGF-β and PI3K/AKT.Targeting CKIP-1 enhances the efficacy of immune checkpoint inhibitors and CAR-T therapy,but clinical translation faces challenges,such as unclear tissue-specific mechanisms and combination toxicity.This review aims to synthesize the regulatory functions of CKIP-1 in the tumor immune microenvironment,thereby offering a theoretical basis for precision immunotherapy targeting CKIP-1 and further analyzing its dynamic mechanisms to advance clinical applications.