基于NF-κB信号通路探讨中药治疗肝癌的研究进展OA
Research Progress on Treatment of Liver Cancer with Mechanistic Insights into Herbal Medicine:Focus on NF-κB Signaling Pathway
肝癌是全球范围内发病率和死亡率较高的恶性肿瘤之一,临床治疗仍面临巨大挑战.NF-κB信号通路在肝癌发生、发展及治疗中扮演着重要的角色,其异常活化与肿瘤细胞增殖、凋亡抑制等过程密切相关.因此,近年来针对该通路的抑制已成为肝癌治疗的重要研究方向.而中药凭借多种类、多效用的作用特点,在肝癌治疗中展现出独特优势.本文系统综述了NF-κB信号通路在肝癌中的调控机制,并总结了中药通过抑制该通路活性、诱导肝癌细胞凋亡来发挥抗肿瘤作用的研究进展,为中药单体及复方抗肝癌研究提供理论依据与新的思路.
Liver cancer ranks among malignancies with high global incidence and mortality rates,presenting significant therapeutic challenges.The NF-κB signaling pathway plays a pivotal role in pathogenesis,progression,and treatment of liver cancer,where its aberrant activation is intricately linked to tumor cell proliferation and the dysregulation of apoptosis.In recent years,targeting the inhibition of this pathway has become an important research direction in the treatment of liver cancer.Traditional Chinese medicine(TCM),characterized by multicomponent nature and multitarget effects,exhibits unique advantages in the management of liver cancer.In this article,the regulatory mechanisms of the NF-κB signaling pathway in liver cancer are systematically reviewed,and the research progress on how TCM exerts antitumor effects by inhibiting this pathway and inducing apoptosis in liver cancer cells is summarized.This work provides a theoretical basis and new insights for the study of single compounds and compound formulations of TCM against liver cancer.
黄恬锞;谢爱泽
530021 南宁,广西医科大学第一附属医院中医科530021 南宁,广西医科大学附属肿瘤医院中医科
医药卫生
NF-κB信号通路中药肝癌细胞凋亡多靶点治疗
NF-κB signaling pathwayTraditional Chinese medicineLiver cancerApoptosisMulti-target therapy
《肿瘤防治研究》 2026 (3)
211-218,8
National Integrated Traditional Chinese and Western Medicine"Flagship"Department Construction Project(No.[2024]221 issued by the Department of Integrated Traditional Chinese and Western Medicine,National Administration of Traditional Chinese Medicine) 国家中西医协同"旗舰"科室建设项目(国中医药综结合函[2024]221号)
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