首页|期刊导航|癌症生物学与医学(英文版)|Expert consensus on the detection and clinical application of tumor mutational burden

Expert consensus on the detection and clinical application of tumor mutational burdenOA

Expert consensus on the detection and clinical application of tumor mutational burden

Zhenying Guo;Xueping Xiang;Peng Luo;Weiwei Pan;Fei Pang;Fan Wu;Dejian Gu;Li Wang;Liping Wang;Youcai Zhu;Li Lin;Weiwen Li;Jing Zhao;Xinqing Lin;Jing Cai;Ling Xu;Jisheng Li;Xiaodong Jiao;Kainan Li;Jia Wei;Huijing Feng;Lin Wang;Yingying Du;Huanwen Wu;Wang Yao;Xuefei Shi;Xiaomin Niu;Dongmei Yuan;Yanwen Yao;Yinbin Zhang;Binbin Song;Wenfeng Li;Jianfei Fu;Hong Wang;Weixing Li;Mingxiang Ye;Dong Wang;Zhaofeng Wang;Qing Ji;Yuan Fang;Qing Wei;Zhen Wang;Bin Wan;Donglai Lv;Xiaofeng Li;Jinpu Yu;Shengjie Yang;Jing Kang;Jiatao Zhang;Chao Zhang;Lin Shi;Yina Wang;Bihui Li;Zhang Zhang;Ke Wang;Zhefeng Liu;Jingping Yuan;Nong Yang;Lin Wu;Xiaobing Chen;Gu Jin;Zhongwu Li;Miao Li;Guansong Wang;Jiandong Wang;Meiyu Fang;Yong Fang;Shuangshuang Wang;Xiaojia Wang;Jing Chen;Yiping Zhang;Xixu Zhu;Yi Shen;Shenglin Ma;Biyun Wang;Lu Si;Yong Song;Yuanzhi Lu;Cong Wang;Aijun Liu;Yuchen Han;Yun Gu;Bingjian Lv;Chunwei Xu;Liping Zhang;Yueping Liu;Xiaobin Cui;Weizhong Gu;Yining Li;Wei Wang;Wenjun Yang;Weiguo Long;Jingjing Xiang;Hong Mou;Shirong Zhang;Biao Liu;Huajuan Ruan;Yubin Wang;Yongjie Zhu;Feng Wang;Zhonghua Wang;Xiaomin Feng;Xing Liu;Peng Li;Min Deng;Yue Hao;Bin Lian;Lili Mao;Qian Wang;Wenxian Wang;Zhengbo Song;Ziming Li;Wenzhao Zhong;Zhijie Wang;Shengxiang Ren;Wenfeng Fang;Xiaotong Hu;Yongchang Zhang;Jingjing Liu;Xiuyu Cai;Anwen Liu;Wen Li;Ping Zhan;Hongbing Liu;Tangfeng Lv;Liyun Miao;Lingfeng Min;Ming Zhao;Yu Chen;Yu Zhang;Zhansheng Jiang;Gen Lin;Long Huang;Xingxiang Pu;Rongbo Lin;Weifeng Liu;Chuangzhou Rao;Chan Xiang;Dongqing Lv;Zongyang Yu;Peng Shen;Xiaoyan Li;Chuanhao Tang;Chengzhi Zhou;Junping Zhang;Junli Xue;Hui Guo;Qian Chu;Yingshi Piao;Rui Meng;Jingxun Wu;Rui Zhang;Jin Zhou;Zhengfei Zhu;Yongheng Li;Hong Qiu;Fan Xia;Yuanyuan Lu;Xiaofeng Chen;Pingli Sun;Rui Ge;Enyong Dai;Yu Han;Jian Zhang;Yinghua Ji;Xianbin Liang;Hongmei Zhang;Xuelei Ma;Xuewen Liu;Yu Yao

Cancer Center,Department of Pathology,Zhejiang Provincial People's Hospital(Affiliated People's Hospital),Hangzhou Medical College,Hangzhou 310014,ChinaDepartment of Pathology,The Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,ChinaDepartment of Oncology,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,ChinaDepartment of Cell Biology,College of Medicine,Jiaxing University,Jiaxing 314001,ChinaDepartment of Medical,Shanghai OrigiMed Co,Ltd,Shanghai 201114,ChinaDepartment of Medical,Menarini Silicon Biosystems SpA,Shanghai 200333,ChinaDepartment of Medical,Geneplus-Beijing,Beijing 102200,ChinaDepartment of Medical,Geneplus-Beijing,Beijing 102200,ChinaDepartment of Oncology,Baotou Cancer Hospital,Baotou 014000,ChinaDepartment of Thoracic Disease Diagnosis and Treatment Center,Zhejiang Rongjun Hospital,The Third Affiliated Hospital of Jiaxing University,Jiaxing 314000,ChinaDepartment of Medical Oncology,Peking University International Hospital,Beijing 102206,ChinaDepartment of Oncology,Lishui Municipal Central Hospital,Lishui 323000,ChinaDepartment of Pathology,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,ChinaState Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510300,ChinaDepartment of Oncology,Second Affiliated Hospital of Nanchang University,Nanchang 330006,ChinaDepartment of Interventional Pulmonary Diseases,Anhui Chest Hospital,Hefei 230011,ChinaDepartment of Medical Oncology,Qilu Hospital,Cheeloo College of Medicine,Shandong University,Jinan 250012,ChinaDepartment of Medical Oncology,Shanghai Changzheng Hospital,Naval Medical University,Shanghai 200070,ChinaDepartment of Oncology,Shandong Provincial Third Hospital,Cheeloo College of Medicine,Shandong University,Jinan 250031,ChinaDepartment of The Comprehensive Cancer Center,Affiliated Drum Tower Hospital,Medical School of Nanjing University,Nanjing 210008,ChinaDepartment of Thoracic Oncology,Shanxi Academy of Medical Sciences,Shanxi Bethune Hospital,Taiyuan 030032,ChinaDepartment of Pathology,Shanxi Academy of Medical Sciences,Shanxi Bethune Hospital,Taiyuan 030032,ChinaDepartment of Oncology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,ChinaDepartment of Pathology,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100730,ChinaDepartment of Interventional Oncology,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510060,ChinaDepartment of Respiratory Medicine,Huzhou Hospital,Zhejiang University School of Medicine,Huzhou 313000,ChinaDepartment of Shanghai Lung Cancer Center,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai 200030,ChinaDepartment of Respiratory Medicine,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,ChinaDepartment of Respiratory Medicine,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,ChinaDepartment of Oncology,The Second Affiliated Hospital of Medical College,Xi'an Jiaotong University,Xi'an 710004,ChinaDepartment of Medical Oncology,The Affiliated Hospital of Jiaxing University,Jiaxing 314000,ChinaDepartment of Radiation Oncology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,ChinaDepartment of Medical Oncology,Affiliated Jinhua Hospital,Zhejiang University School of Medicine,Jinhua 321000,ChinaSenior Department of Oncology,The 5th Medical Center of PLA General Hospital,Beijing 100071,ChinaLaboratory Medicine Center,Zhejiang Center for Clinical Laboratory,Zhejiang Provincial People's Hospital,Affiliated People's Hospital,Hangzhou Medical College,Hangzhou 310014,ChinaDepartment of Respiratory Medicine,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,ChinaDepartment of Respiratory Medicine,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,ChinaDepartment of Respiratory Medicine,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,ChinaDepartment of Chemotherapy,Chinese Academy of Sciences University Cancer Hospital(Zhejiang Cancer Hospital),Hangzhou 310022,ChinaDepartment of Pathology,Anhui Provincial Children's Hospital,Hefei 230051,ChinaDepartment of Chemotherapy,Chinese Academy of Sciences University Cancer Hospital(Zhejiang Cancer Hospital),Hangzhou 310022,ChinaDepartment of Radiation Oncology,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,ChinaDepartment of Respiratory Medicine,The Affiliated Jiangning Hospital of Nanjing Medical University,Nanjing 210002,ChinaDepartment of Clinical Oncology,The 901 Hospital of Joint Logistics Support Force of People Liberation Army,Hefei 230031,ChinaDepartment of Thoracic Disease Diagnosis and Treatment Center,Zhejiang Rongjun Hospital,The Third Affiliated Hospital of Jiaxing University,Jiaxing 314000,ChinaDepartment of Cancer Molecular Diagnostics Core,Tianjin Medical University Cancer Institute and Hospital,Tianjin 300060,ChinaDepartment of Thoracic Surgery,Chuxiong Yi Autonomous Prefecture People's Hospital,Chuxiong 675000,ChinaGuangdong Lung Cancer Institute,Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,School of Medicine,Guangzhou 510080,ChinaGuangdong Lung Cancer Institute,Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,School of Medicine,Guangzhou 510080,ChinaGuangdong Lung Cancer Institute,Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,School of Medicine,Guangzhou 510080,ChinaDepartment of Respiratory Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032,ChinaDepartment of Oncology,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310000,ChinaDepartment of Oncology,The Second Affiliated Hospital of Guilin Medical University,Guilin 541199,ChinaInternational Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education(MOE),Guangzhou City Key Laboratory of Precision Chemical Drug Development,School of Pharmacy,Jinan University,Guangzhou 510632,ChinaNational Health Commission(NHC)Key Laboratory of Nuclear Medicine,Jiangsu Key Laboratory of Molecular Nuclear Medicine,Jiangsu Institute of Nuclear Medicine,Wuxi 214063,China||Department of Radiopharmaceuticals,School of Pharmacy,Nanjing Medical University,Nanjing 210000,ChinaSenior Department of Oncology,The 5th Medical Center of PLA General Hospital,Beijing 100071,ChinaDepartment of Pathology,Renmin Hospital of Wuhan University,Wuhan 430060,ChinaDepartment of Medical Oncology,Lung Cancer and Gastrointestinal Unit,Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha 410013,ChinaThe Second Department of Thoracic Oncology,Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha 410013,ChinaDepartment of Oncology,The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital,Zhengzhou 450008,ChinaDepartment of Bone and Soft-tissue Surgery,Chinese Academy of Sciences University Cancer Hospital(Zhejiang Cancer Hospital),Hangzhou 310022,ChinaKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Department of Pathology,Peking University Cancer Hospital&Institute,Beijing 100142,ChinaDepartment of Oncology,The Cancer Hospital of Qinghai Province,Xining 810001,ChinaInstitute of Respiratory Diseases,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,ChinaDepartment of Pathology,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,ChinaDepartment of Chemotherapy,Chinese Academy of Sciences University Cancer Hospital(Zhejiang Cancer Hospital),Hangzhou 310022,ChinaDepartment of Medical Oncology,Sir Run Run Shaw Hospital,Zhejiang University,Hangzhou 310016,ChinaDepartment of Pathology,Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,ChinaDepartment of Chemotherapy,Chinese Academy of Sciences University Cancer Hospital(Zhejiang Cancer Hospital),Hangzhou 310022,ChinaCancer Center,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,ChinaDepartment of Chemotherapy,Chinese Academy of Sciences University Cancer Hospital(Zhejiang Cancer Hospital),Hangzhou 310022,ChinaDepartment of Radiation Oncology,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,ChinaDepartment of Thoracic Surgery,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,ChinaDepartment of Oncology,Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province,Affiliated Hangzhou Cancer Hospital,Cancer Center,Westlake University School of Medicine,Hangzhou 310006,ChinaDepartment of Breast Cancer and Urological Medical Oncology,Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,ChinaKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Department of Melanoma and Sarcoma,Peking University Cancer Hospital&Institute,Beijing 100142,ChinaDepartment of Respiratory Medicine,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,ChinaDepartment of Clinical Pathology,The First Affiliated Hospital of Jinan University,Guangzhou 510630,ChinaDepartment of Pathology,The First Affiliated Hospital of Nanjing Medical University(Jiangsu Province Hospital),Nanjing 210029,ChinaSenior Department of Pathology,the 7th Medical Center of PLA General Hospital,Beijing 100700,ChinaDepartment of Pathology,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai 200030,ChinaDepartment of Pathology,Women's Hospital of Nanjing Medical University,Nanjing Women and Children's Healthcare Hospital,Nanjing 210004,ChinaDepartment of Surgical Pathology Women's Hospital,School of Medicine,Zhejiang University,Hangzhou 310006,of ChinaHangzhou Institute of Medicine(HIM),Chinese Academy of Sciences,Hangzhou 310022,ChinaDepartment of Pathology,Shanghai Pudong Hospital,School of Medicine,Fudan University,Shanghai 201399,ChinaDepartment of Pathology,The Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,ChinaDepartment of Pathology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,ChinaDepartment of Pathology,Children's Hospital Zhejiang University School of Medicine,Hangzhou 310005,ChinaDepartment of Pathology,Stomatology Hospital,School of Stomatology,Zhejiang University,Hangzhou 310000,ChinaDepartment of Pathology,Tongde Hospital of Zhejiang Province,Hangzhou 310012,ChinaDepartment of Pathology,Affiliated Hospital of Hangzhou Normal University,Hangzhou 310000,ChinaDepartment of Pathology,The People's Hospital of Leshan,Leshan 614000,ChinaDepartment of Pathology,Affiliated Hangzhou First People's Hospital,Westlake University School of Medicine,Hangzhou 310006,ChinaDepartment of Pathology,Chun'an First People's Hospital,Hangzhou 311700,ChinaTranslational Medicine Research Center,Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province,Affiliated Hangzhou First People's Hospital,Cancer Center,Westlake University School of Medicine,Hangzhou 310006,ChinaDepartment of Pathology,The Affiliated Suzhou Hospital,Nanjing Medical University,Suzhou 215006,ChinaDepartment of Pathology,The First People's Hospital of Hangzhou Lin'an District,Affiliated Lin'an People's Hospital,Hangzhou Medical College,Hangzhou 311300,ChinaDepartment of Pathology,Tiantai County People's Hospital,Taizhou 317200,ChinaDepartment of Pathology,First People's Hospital of Aksu,Aksu 843000,ChinaDepartment of Pathology,Xianju People's Hospital,Zhejiang Southeast Campus of Zhejiang Provincial People's Hospital,Affiliated Xianju's Hospital,Hangzhou Medical College,Taizhou 317300,ChinaDepartment of Pathology,Dinghai Branch of Zhejiang Provincial People's Hospital,Zhoushan 316000,ChinaDepartment of Pathology,Women's Hospital of Nanjing Medical University,Nanjing Women and Children's Healthcare Hospital,Nanjing 210004,ChinaDepartment of Pathology,Shulan(Hangzhou)Hospital,Hangzhou 310022,ChinaDepartment of Pathology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,ChinaDepartment of Pathology,Zhejiang Provincial People's Hospital(Fuyang Campus),Hangzhou 311400,ChinaDepartment of Chemotherapy,Chinese Academy of Sciences University Cancer Hospital(Zhejiang Cancer Hospital),Hangzhou 310022,ChinaKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Department of Melanoma and Sarcoma,Peking University Cancer Hospital&Institute,Beijing 100142,ChinaKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Department of Melanoma and Sarcoma,Peking University Cancer Hospital&Institute,Beijing 100142,ChinaDepartment of Respiratory Medicine,Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,ChinaDepartment of Chemotherapy,Chinese Academy of Sciences University Cancer Hospital(Zhejiang Cancer Hospital),Hangzhou 310022,ChinaDepartment of Chemotherapy,Chinese Academy of Sciences University Cancer Hospital(Zhejiang Cancer Hospital),Hangzhou 310022,ChinaDepartment of Shanghai Lung Cancer Center,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai 200030,ChinaGuangdong Lung Cancer Institute,Guangdong Provincial Laboratory of Translational Medicine in Lung Cancer,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,School of Medicine,Guangzhou 510080,ChinaState Key Laboratory of Molecular Oncology,Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,ChinaDepartment of Medical Oncology,Shanghai Pulmonary Hospital,School of Medicine,Tongji University,Shanghai 200433,ChinaDepartment of Medical Oncology,Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangzhou 510060,ChinaDepartment of Pathology,Sir Run Run Shaw Hospital,Zhejiang University,Hangzhou 310016,ChinaDepartment of Medical Oncology,Lung Cancer and Gastrointestinal Unit,Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha 410013,ChinaDepartment of Thoracic Cancer,Jilin Cancer Hospital,Changchun 130012,ChinaDepartment of VIP Inpatient,Sun Yat-Sen University Cancer Center,State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangzhou 510060,ChinaDepartment of Oncology,Second Affiliated Hospital of Nanchang University,Nanchang 330006,ChinaKey Laboratory of Respiratory Disease of Zhejiang Province,Department of Respiratory and Critical Care Medicine,Second Affiliated Hospital of Zhejiang University School of Medicine,Cancer Center,Zhejiang University,Hangzhou 310009,ChinaDepartment of Respiratory Medicine,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,ChinaDepartment of Respiratory Medicine,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,ChinaDepartment of Respiratory Medicine,Affiliated Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,ChinaDepartment of Respiratory Medicine,Affiliated Drum Tower Hospital,Medical School of Nanjing University,Nanjing 210008,ChinaDepartment of Respiratory Medicine,Clinical Medical School of Yangzhou University,Subei People's Hospital of Jiangsu Province,Yangzhou 225001,ChinaNingbo Clinical Pathology Diagnosis Center,Ningbo 315100,ChinaDepartment of Medical Oncology,Fujian Medical University Cancer Hospital&Fujian Cancer Hospital,Fuzhou 350014,ChinaDepartment of Oncology,Guizhou Provincial People's Hospital,Guiyang 550001,ChinaDepartment of Integrative Oncology,Tianjin Medical University Cancer Institute and Hospital,Tianjin 300060,ChinaDepartment of Medical Oncology,Fujian Medical University Cancer Hospital&Fujian Cancer Hospital,Fuzhou 350014,ChinaDepartment of Oncology,Second Affiliated Hospital of Nanchang University,Nanchang 330006,ChinaThe Second Department of Thoracic Oncology,Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha 410013,ChinaDepartment of Medical Oncology,Fujian Medical University Cancer Hospital&Fujian Cancer Hospital,Fuzhou 350014,ChinaDepartment of Orthopedic Oncology Surgery,Beijing Ji shui tan Hospital,Peking University,Beijing 100035,ChinaDepartment of Radiotherapy and Chemotherapy,Hwamei Hospital,University of Chinese Academy of Sciences,Ningbo 315010,ChinaDepartment of Pathology,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai 200030,ChinaDepartment of Pulmonary Medicine,Taizhou Hospital of Wenzhou Medical University,Taizhou 317000,ChinaDepartment of Respiratory Medicine,the 900th Hospital of the Joint Logistics Team(the Former Fuzhou General Hospital),Fujian Medical University,Fuzhou 350025,ChinaDepartment of Oncology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,ChinaDepartment of Oncology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100700,ChinaDepartment of Medical Oncology,Peking University International Hospital,Beijing 102206,ChinaState Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510300,ChinaDepartment of Thoracic Oncology,Shanxi Academy of Medical Sciences,Shanxi Bethune Hospital,Taiyuan 030032,ChinaDepartment of Oncology,Shanghai East Hospital,School of Medicine,Tongji University,Shanghai 200123,ChinaDepartment of Oncology,The Second Affiliated Hospital of Medical College,Xi'an Jiaotong University,Xi'an 710004,ChinaDepartment of Oncology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,ChinaDepartment of Pathology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,ChinaCancer Center,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,ChinaDepartment of Medical Oncology,The First Affiliated Hospital of Medicine,Xiamen University,Xiamen 361003,ChinaDepartment of Medical Oncology,Cancer Hospital of China Medical University,Shenyang 110042,ChinaDepartment of Medical Oncology,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology,Chengdu 610041,ChinaDepartment of Radiation Oncology,Fudan University Shanghai Cancer Center,Shanghai 200032,ChinaKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Department of Radiation Oncology,Peking University Cancer Hospital&Institute,Beijing 100142,ChinaDepartment of Oncology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,ChinaDepartment of Radiation Oncology,Fudan University Shanghai Cancer Center,Shanghai 200032,ChinaState Key Laboratory of Cancer Biology,National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases,Fourth Military Medical University,Xi'an 710032,ChinaDepartment of Oncology,Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital,Nanjing 210029,ChinaDepartment of Pathology,The Second Hospital of Jilin University,Changchun 130041,ChinaDepartment of General Surgery,Huadong Hospital Affiliated to Fudan University,Shanghai 200040,ChinaDepartment of Oncology and Hematology,China-Japan Union Hospital of Jilin University,Changchun 130033,ChinaDepartment of Gastrointestinal Oncology,Harbin Medical University Cancer Hospital,Harbin 150081,ChinaDepartment of Oncology,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,ChinaDepartment of Oncology,The First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453000,ChinaDepartment of Oncology,The Third People's Hospital of Zhengzhou,Zhengzhou 450000,ChinaDepartment of Biotherapy,State Key Laboratory of Biotherapy,Cancer Center,West China Hospital,Sichuan University,Chengdu 610041,ChinaDepartment of Biotherapy,State Key Laboratory of Biotherapy,Cancer Center,West China Hospital,Sichuan University,Chengdu 610041,ChinaDepartment of Oncology,the Third Xiangya Hospital,Central South University,Changsha 410013,ChinaDepartment of Medical Oncology,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China

Biomarkerstumor mutational burdentumor immunotherapytargeted panel sequencingwhole-exome sequencing

Biomarkerstumor mutational burdentumor immunotherapytargeted panel sequencingwhole-exome sequencing

《癌症生物学与医学(英文版)》 2026 (2)

218-246,29

This research was supported by grants from the National Natural Science Foundation of China(Grant No.82072577)and from the International Medical Association(Grant No.IMA-F-2025-001).

10.20892/j.issn.2095-3941.2025.0351

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