基于"脾为之卫"探讨肠道菌群在儿童孤独症谱系障碍的作用机制OA

Autism spectrum disorder(ASD)is a neurodevelopmental disorder with a complex pathogenesis,closely associated with gut microbiota dysbiosis and the function of the"spleen"in traditional Chinese medicine(TCM).The theory of"spleen acts as the defender"emphasizes the critical role of the spleen in human defense mechanisms,involving functions such as transportation and transformation,consolidation of defensive qi,and coordination of qi and blood.Clinical studies have shown that children with ASD commonly exhibit spleen-stomach dysfunction and gut microbiota imbalances.These two factors interact through the"microbiota-gut-brain axis",influencing the pathogenesis of ASD via neural,metabolic,and immune pathways.By integrating TCM theory with modern microbiological research,it is proposed that"spleen acts as the defender"is one of the core pathological mechanisms of ASD.Treatment focusing on the spleen can exert therapeutic effects through multiple pathways,including regulating gut microbiota regulation,intestinal barrier function improvement,and inflammatory responses inhibition.Based on the principle of"fortifying the spleen and consolidating defensive qi",an integrated Chinese-Western medicine intervention strategy offers the advantages of multi-target and holistic regulation.