胎儿脐动脉超声参数联合血清VEGF水平检测对子痫前期患者妊娠结局的预测价值OA
Predictive value of combining fetal umbilical artery ultrasound parameters with serum VEGF level detection for pregnancy outcomes in patients with preeclampsia
目的 分析胎儿脐动脉超声参数联合血清血管内皮生长因子(VEGF)水平检测对子痫前期患者妊娠结局的预测价值.方法 选取2023年1月至2024年1月焦作市妇幼保健院收治的114例子痫前期患者,根据妊娠结局分为良好组与不良组,比较两组胎儿脐动脉超声参数,包括收缩期与舒张期血流速度比(S/D)、阻力指数(RI)、搏动指数(PI)及血清VEGF水平,分析各指标与妊娠结局的相关性及其对不良妊娠结局的预测价值.结果 不良组超声参数S/D、RI、PI均高于良好组,血清VEGF水平低于良好组(P＜0.05);胎儿脐动脉超声参数S/D、RI、PI与妊娠结局呈正相关,血清VEGF水平与妊娠结局呈负相关(P＜0.05);胎儿脐动脉超声参数S/D、RI、PI、血清VEGF水平及其联合检测预测不良妊娠结局的曲线下面积(AUC)分别为0.745、0.760、0.739、0.737、0.906,约登指数分别为0.388、0.453、0.409、0.456、0.738(P＜0.05);脐动脉超声参数S/D、RI、PI及血清VEGF高水平患者发生妊娠结局不良的危险度是低水平的2.511倍、3.087倍、2.613倍、0.453倍(P＜0.05).结论 胎儿脐动脉超声参数S/D、RI、PI及血清VEGF水平与子痫前期患者妊娠结局关系密切,各指标联合检测对预测不良妊娠结局具有一定的临床参考价值.
[Objective]To analyze the predictive value of combining fetal umbilical artery ultrasound parameters with serum vascular endothelial growth factor(VEGF)levels for pregnancy outcomes in patients with preeclampsia.[Methods]A total of 114 patients with preeclampsia were selected from January 2023 to January 2024 and categorized into a group with good pregnancy outcomes and a group with adverse pregnancy outcomes based on their pregnancy outcomes.The systolic to diastolic blood flow velocity ratio(S/D),resistance index(RI),pulsatility index(PI)of fetal umbilical artery ultrasound parameters,and serum VEGF levels,were compared between the two groups.The correlation between each indicator and pregnancy outcomes was analyzed,as well as their predictive value for adverse pregnancy outcomes.[Results]The S/D,RI,and PI of ultrasound parameters in the group with adverse pregnancy outcomes were significantly higher than those in the group with good pregnancy outcomes,while the serum VEGF level was significantly lower than that in the group with good pregnancy outcomes,with statistical significance differences(P＜0.05).The S/D,RI,and PI of fetal umbilical artery ultrasound parameters were positively correlated with pregnancy outcomes,while the serum VEGF level was negatively correlated with pregnancy outcomes,with statistical significance differences(P＜0.05).The area under the curve(AUC)for predicting adverse pregnancy outcomes using the combined detection of fetal umbilical artery ultrasound parameters S/D,RI,PI,and serum VEGF levels were 0.745,0.760,0.739,0.737,0.906,with Youden's indices of 0.388,0.453,0.409,0.456 and 0.738,respectively,the differences were statistically significant(P＜0.05).Patients with high levels of umbilical artery ultrasound parameters S/D,RI,PI,and serum VEGF had a 2.511-fold,3.087-fold,2.613-fold,and 0.453-fold higher risk of adverse pregnancy outcomes compared with those with low levels,respectively,the differences were statistically significant(P＜0.05).[Conclusion]The S/D,RI,PI of ultrasound parameters of fetal umbilical artery,and serum VEGF levels,are closely related to the pregnancy outcomes of patients with preeclampsia.The combined detection of these indicators can provide certain reference value for clinical prediction of adverse pregnancy outcomes.
李梦云;原春花;张海花
焦作市妇幼保健院 超声医学科,河南 焦作 454000焦作市妇幼保健院 医学遗传与产前诊断科,河南 焦作 454000焦作市妇幼保健院 超声医学科,河南 焦作 454000
医药卫生
子痫前期收缩期与舒张期血流速度比阻力指数搏动指数血清血管内皮生长因子妊娠结局
preeclampsiasystolic to diastolic blood flow velocity ratio(S/D)resistance index(RI)pulsatility index(PI)vascular endothelial growth factor(VEGF)pregnancy outcome
《中国医学工程》 2026 (2)
45-49,5
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