癌组织驱动蛋白20A、叉头框蛋白A2表达水平与老年结直肠癌患者病理特征及根治术后预后的相关性分析OA
Correlation analysis of expression levels of kinesin-like protein 20A and forkhead box protein A2 in cancer tissues with pathological characteristics and postoperative prognosis of elderly patients with colorectal cancer after radical resection
目的 探讨癌组织驱动蛋白20A(KIF20A)、叉头框蛋白A2(FOXA2)表达水平与老年结直肠癌患者病理特征及根治术后预后的相关性.方法 回顾性选取2021年2月至2024年8月濮阳市人民医院收治的结直肠癌患者89例为研究对象,比较不同病理特征患者KIF20A、FOXA2表达水平.依据患者术后6个月预后情况,分别纳入良好组(65例)、不良组(24例).比较两组一般资料及癌组织KIF20A、FOXA2表达水平,分析患者预后的影响因素及癌组织KIF20A、FOXA2表达水平对患者预后不良风险的交互作用.结果 不同分化程度、病理分级、淋巴结转移情况患者癌组织KIF20A、FOXA2表达水平比较,差异有统计学意义(P＜0.05);不良组低分化程度、病理分级Ⅲ～Ⅳ级、有淋巴结转移、癌组织KIF20A、FOXA2表达阳性患者占比高于良好组(P＜0.05);癌组织KIF20A、FOXA2表达水平为患者预后的独立影响因素(P＜0.05);癌组织KIF20A、FOXA2表达水平对患者预后不良风险具有正向相加交互作用(P＜0.05).结论 癌组织KIF20A、FOXA2表达水平与老年结直肠癌患者病灶分化程度、病理分级、淋巴结转移情况及根治术后预后情况有关,且KIF20A、FOXA2表达水平对患者预后不良风险有正向相加交互作用,临床可通过检测二者表达水平对患者预后进行预测,以指导临床治疗工作.
[Objective]To investigate the correlation between the expression levels of kinesin-like protein 20A(KIF20A)and forkhead box protein A2(FOXA2)in cancer tissues and the pathological characteristics as well as postoperative prognosis of elderly patients with colorectal cancer.[Methods]A retrospective study was conducted on 89 colorectal cancer patients admitted to Puyang People's Hospital from February 2021 to August 2024,who were selected as the research subjects.The expression levels of KIF20A and FOXA2 were compared among patients with different pathological characteristics.Based on the prognosis of patients six months after surgery,they were categorized into a good group(65 cases)and a poor group(24 cases).The general information and expression levels of KIF20A and FOXA2 in cancer tissues were compared between the two groups.The influencing factors of patient prognosis and the interaction between the expression levels of KIF20A and FOXA2 in cancer tissues and the risk of poor prognosis were analyzed.[Results]The expression levels of KIF20A and FOXA2 in cancer tissues of patients with different differentiation levels,pathological grading,and lymph node metastasis were compared,and the differences were statistically significant(P＜0.05).The proportion of patients with poor differentiation,pathological grade Ⅲ-Ⅳ,lymph node metastasis,and positive expression of KIF20A and FOXA2 in cancer tissue was higher in the poor group than in the good group,and the difference was statistically significant(P＜0.05).The expression levels of KIF20A and FOXA2 in cancer tissues were independent factors affecting patient prognosis,and the differences were statistically significant(P＜0.05).The expression levels of KIF20A and FOXA2 in cancer tissues had a positive additive interaction with the risk of poor prognosis in patients,and the differences were statistically significant(P＜0.05).[Conclusion]The expression levels of KIF20A and FOXA2 in cancer tissues are associated with the degree of lesion differentiation,pathological grading,lymph node metastasis,and prognosis after radical resection in elderly patients with colorectal cancer.Furthermore,the expression levels of KIF20A and FOXA2 have a positive additive interaction on the risk of poor prognosis in patients.Clinically,the prognosis of patients can be predicted by detecting the expression levels of these two genes to guide clinical treatment.
赵九英;孙丽丽;刘金霞
濮阳市人民医院 病理科,河南 濮阳 457100濮阳市人民医院 病理科,河南 濮阳 457100濮阳市人民医院 病理科,河南 濮阳 457100
医药卫生
结直肠癌老年癌组织驱动蛋白20A叉头框蛋白A2病理特征根治术预后相关性
colorectal cancerelderlycancer tissuekinesin 20Aforkhead box protein A2pathological characteristicsradical resectionprognosiscorrelation
《中国医学工程》 2026 (2)
33-38,6
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