血常规指标联合C反应蛋白对菌血症的早期诊断效能分析OA

Objective To explore the diagnostic value of blood routine test indexes combined with C-reactive protein(CRP)for the early diagnosis of bacteremia.Methods A retrospective analysis was conducted on the clinical data of 368 inpatients admitted to the People's Hospital of Wuzhou from January 2024 to October 2025.They were divided into bacteremia group(n=170),local infection group(n=98),and non-infection group(n=100).The data of neutrophil(NEUT),lymphocyte(LYM),platelet(PLT)and CRP within 6 hours after blood culture sampling were obtained for all patients,and neutrophil to lymphocyte ratio(NLR)and platelet to lymphocyte ratio(PLR)were calculated.The diagnostic efficacy of each indicator,as well as their combined application,were evaluated using the receiver operating characteristic(ROC)curve.Results There were statistically significant differences in the levels of NEUT,LYM,PLT,NLR,PLR and CRP among three groups of patients(P<0.05).The NEUT,NLR,PLR and CRP levels of patients in bacteremia group were significantly higher than those in other two groups(P<0.05),while the LYM and PLT levels were significantly lower than those in other two groups(P<0.05).The ROC curve results showed that the combined diagnosis of bacteremia using NLR+PLR+CRP had the highest efficacy[area under the curve(AUC)=0.880,95%CI:0.847-0.914],with a sensitivity of 85.3%,a specificity of 74.7%,and a Youden index of 0.600.The diagnostic efficacy of NLR in a single indicator was the best(AUC=0.860).Conclusion The combined detection of NLR,PLR,and CRP holds significant auxiliary diagnostic value for the early identification of bacteremia and can be used for rapid screening and clinical decision support prior to the availability of blood culture results.