认知储备与帕金森病脑电活动的相关性研究OA

Objective To explore the associations between cognitive reserve and cerebral electrical activity in patients with Parkinson's disease(PD).Methods Thirty-one PD patients who visited the Third Affiliated Hospital of Anhui Medical University from June 2024 to June 2025 were selected and included in PD group.Meanwhile,28 healthy individuals who underwent physical examinations with matched demographic data were selected and included in control group.The cognitive reserve,neuropsychology,and the power spectral density and relative power of different brain regions in various frequency bands of electroencephalogram were assessed and compared between two groups.Results The scores of mini-mental state examination(MMSE),cognitive reserve index(CRI)questionnaire,digital span test-forward,frontal assessment battery and digt symbol substitution test in PD group were significantly lower than those in control group,while the scores of Hamilton anxiety scale and Hamilton depression scale were significantly higher than those in control group(P<0.05).The MMSE score of patients in PD group was positively correlated with the total score of CRI,years of education and leisure time(P<0.05).The power spectral densities of δ waves and θ waves in the anterior,central and posterior regions of patients in PD group were all higher than those in control group(P<0.05).The total score of CRI of patients in PD group was negatively correlated with δ wave and θ wave in the anterior region(P<0.05),and positively correlated with high-β wave in both the anterior and central regions(P<0.05).Conclusion Higher educational attainment and sufficient leisure activities can delay the cognitive decline of PD patients by enhancing cognitive reserves.The changes in electroencephalogram rhythms in the frontal and the central-temporal regions may be related to cognitive reserve.