绿原酸治疗中枢神经系统疾病作用及其机制研究进展OA

Currently,long-term use of clinical therapeutic drugs for central nervous system(CNS)diseases is prone to diminished efficacy and adverse reactions.As a natural polyphenolic compound,chlorogenic acid(CGA)has been proven to possess significant central neuroprotective activity.It exhibits multi-targeted and multi-pathway synergistic therapeutic mechanisms,which mainly include inhibiting inflammatory signaling axes and the release of pro-inflammatory factors to exert anti-inflammatory effects,enhancing antioxidant enzyme activity to alleviate oxidative stress damage,regulating synaptic expression and hippocampal synaptic plasticity,stabilizing mitochondrial function to inhibit neuronal apoptosis and ferroptosis,and regulating the microbiota-neuroimmune crosstalk network via the gut-brain axis.This review summarizes the molecular mechanisms through which CGA exerts therapeutic effects on Alzheimer's disease(AD),Parkinson's disease(PD),epilepsy,stroke,depression,anxiety,spinal cord injury(SCI),chronic pain,and post-traumatic stress disorder(PTSD),as well as the innovative applications of related nano-delivery technologies and combined therapeutic strategies.This review aims to comprehensively clarify the multidimensional neuroprotective mechanisms of CGA,thereby providing new ideas and a theoretical basis for the development of related drugs and the prevention and treatment of CNS diseases.