基于UPLC-Q-TOF-MS/MS的杏荷止咳糖浆化学成分鉴别及指纹图谱分析OA

Objective:To qualitatively analyze the chemical components and establish the fingerprint of Xinghe Zhike Syrup.Methods:Ultra-high performance liquid chromatography-quadrupole-time-of-flight tandem mass spectrometry(UPLC-Q-TOF-MS/MS)was employed to identify the chemical components of Xinghe Zhike Syrup.Ultra-high performance liquid chromatography-evaporative light scattering detector(UPLC-ELSD)was employed to establish the fingerprints of 15 batches of Xinghe Zhike Syrup,and the Similarity Evaluation System for Chromatographic Fingerprint of Traditional Chinese Medicine was used for similarity evaluation.Results:A total of 41 compounds in Xinghe Zhike Syrup were identified,mainly including flavonoids,phenolic acids,terpenoids,and saponins.There were 17 common peaks in the fingerprints of the 15 batches of Xinghe Zhike Syrup,with similarities ranging from 0.949 to 0.999,and 16 common peaks were identified.Conclusion:The chemical components of Xinghe Zhike Syrup were clarified,and the established fingerprinting method for Xinghe Zhike Syrup is simple and accurate,providing a reference for improving its quality evaluation standard.