川芎中21种元素分析及风险评估OA

Objective:To determine the content of 21 elements in Ligusticum chuanxiong herbs,stems,leaves,rhizosphere soil,and irrigation water,and assess the risk of toxic elements in the medicinal material,including Pb,Cd,As,Hg,Cu,Al,Cr,and Ni,aiming to provide a basis for the quality and safety evaluation of L.chuanxiong.Methods:After microwave digestion,inductively coupled plasma mass spectrometry(ICP-MS)was employed to analyze 21 elements.Based on the results,health risks were assessed.Results:The 21 elements exhibited good linearity and precision,with limits of detection ranging from 0.001 to 0.612 μg·kg-1,and recovery rates of 85%-115%.The mass fractions of K,Ca,Fe,Al,and Na in L.chuanxiong were greater than 50 mg·kg-1,accounting for a high proportion.The hazard index(HI)of harmful elements in five batches of samples was less than 1,indicating a low and acceptable non-carcinogenic risk.The carcinogenic risk(CR)of Pb and As was lower than 1×10-4,indicating a low and acceptable carcinogenic risk.There was a significant positive correlation between the heavy metal content in L.chuanxiong herbs and that in the stems and leaves.Conclusion:The multi-element analysis method established in this study demonstrates satisfactory specificity and sensitivity.Combined with risk assessment technology,it can provide technical support for the quality safety evaluation of L.chuanxiong.