基于多组学的特发性肺纤维化中医药研究思路与方法OA

Idiopathic pulmonary fibrosis(IPF)has become an important public health problem to be solved due to its increasing incidence,limited treatment options and poor prognosis.Clinical application of TCM in the treatment of IPF can effectively relieve the symptoms of patients,reduce the frequency of acute exacerbation,and improve the quality of life of patients.Multi-omics is an extension of systems biology,integrating multi-dimensional data such as the genome,transcriptome,proteome and metabolome to reveal the biological basis of disease progression at the molecular level.This article combined multi-omics with TCM theories,and based on an integrated research framework encompassing"disease-syndrome-compound-effect",and excavated the key biomarkers of TCM in the diagnosis and treatment of IPF,so as to provide theoretical reference for the standardization and objectification of TCM syndrome differentiation and treatment.