慢性子宫内膜炎患者血清MCP-1水平及其与子宫内膜息肉、炎症反应的相关性OA

Objective To investigate the correlation between monocyte chemoattractant protein-1(MCP-1)levels and endometrial polyps(EP)as well as inflammatory responses in patients with chronic endometritis(CE).Methods A total of 157 patients with CE admitted to the Department of Gynecology of our hospital between June 2021 and June 2024 were selected as study participants.The dif-ferences in MCP-1 level among patients with CE with different clinical characteristics were observed,and stratified regression analysis was used to examine the relationship between different clinical characteristics and MCP-1 level.Based on hysteroscopic pathological results,the patients were divided into the EP group and the non-EP group.The general data,serum sex hormones,and inflammatory markers of the two groups were compared.Multiple linear regression analysis was used to analyze the relationship between MCP-1 levels and serum sex hormones and inflammatory markers.Logistic regression analysis was used for influencing factor analysis.Unconditional logistic regression and restricted cubic spline models were used to analyze the association and dose-response relationship between MCP-1 levels in patients with CE and EP.A generalized multifactor dimensionality reduction(GMDR)model was used to analyze the interaction between MCP-1 and inflammatory markers in patients with CE and EP.Results In patients with CE,the number of abortions,abnormal leukorrhea,abnormal uterine bleeding,pelvic pain,and ectopic pregnancy were significantly correlated with MCP-1 levels(P<0.05).The levels of follicle stimulating hormone(FSH),estradiol(E2),luteinizing hormone(LH),interleukin-6(IL-6),tumor necrosis factor α(TNF-α),interleukin-1β(IL-1β),and C-reactive protein(CRP)in the EP group were significantly higher than those in the non-EP group.MCP-1,estradiol(E2),TNF-α,IL-1β,and IL-6 were independent risk factors for CE complicated by EP(P<0.05).There was a non-linear relationship between MCP-1 and EP risk,which increased significantly when MCP-1 was>30.30 ng/mL(nonlinear test,P<0.001).The best interaction model was the synergistic effect of MCP-1,TNF-α,IL-1β,and IL-6 overexpression(P<0.05).Conclusion In patients with CE,MCP-1 levels are closely associated with EP occurrence and are positively regulated by the sex hormone E2 and inflammatory indicators.Additionally,significant interactions between MCP-1 and inflammatory indicators exist in CE combined with EP,suggesting that MCP-1 may play a key role in the occurrence and development of CE combined with EP.