外周血Hsa-circRNA0001380水平对急性前壁ST段抬高型心肌梗死后心力衰竭的预测价值OA

Objective To explore the predictive value of Hsa-circRNA0001380 for heart failure after emergency percutaneous coro-nary intervention(PCI)in patients with acute anterior wall ST-segment elevation myocardial infarction(STEMI).Methods Sixty-two patients with acute anterior wall STEMI who underwent emergency PCI at the Dalian University of Technology Affiliated Cen-tral Hospital between January and December 2022 were enrolled.Twenty-two healthy volunteers served as controls.In the STEMI group,Hsa-circRNA0001380 levels were compared across the different cardiac function indicators.Receiver operating characteri-stic(ROC)curves were used to eva-luate the predictive value of heart failure after acute anterior wall STEMI.Results Hsa-cir-cRNA0001380 expression was significantly increased in patients with STEMI than in controls(P<0.01)and correlated with Killip classification and left ventricular ejection fraction(LVEF)(both P<0.01).Patients were divided into the high-level group(≥0.012 7,n=31)and low-level group(<0.012 7,n=31)according to the median value of Hsa-circRNA0001380.Hsa-cir-cRNA0001380 was positively correlated with left ventricular end-diastolic volume(r=0.594)and NT-proBNP(r=0.644)but negatively correlated with LVEF(r=-0.838)(all P<0.01).The area under the ROC curve for predicting heart failure was 0.953.Conclusion Peripheral blood Hsa-circRNA0001380 is significantly upregulated in acute anterior wall STEMI,especially in patients with heart failure,and may be a novel molecular marker for predicting the progression of heart failure after acute anterior wall STEMI.