闭环脊髓神经接口联合康复训练治疗不完全性脊髓损伤患者一例OA

Spinal cord injury(SCI)is a major cause of motor disability.Epidural electrical stimulation(EES)has emerged as a promising neuromodulation technique and has been extensively investigated in recent years for promoting functional recovery after SCI.This case report describes a patient who sustained a thoracic SCI four months ago due to a fall from height.Following surgical intervention and conventional rehabilitation,the patient's lower limb muscle strength remained at grade C on the American Spinal Injury Association(ASIA)impairment scale.After implantation of a closed-loop spinal neural interface for EES,the patient underwent a regimen of continuous stimulation with spatially targeted configurations and multimodal rehabilitation training.This intervention led to progressive recovery,including the achievement of voluntary single-joint movements,independent standing,and assisted walking.At the 16-week follow-up,the patient's ASIA grade improved from C to D.Improvements were also noted in sensory and autonomic functions in addition to motor recovery.The overall rehabilitation outcomes were substan-tially better than those typically reported for chronic-phase SCI patients in the literature.Importantly,no implant-related infections or neurological complications were observed.These results indicate that the combination of closed-loop spinal neural interface-enabled EES and structured rehabilitation holds significant potential as a therapeutic strategy.