肠杆菌目细菌血流感染中西医临床特点及预后危险因素分析OA

Objective:To explore the clinical characteristics of integrated Traditional Chinese and Western Med-icine(TCM-WM)and risk factors for short-term death in patients with Enterobacterales Bloodstream Infection(EB-BSI)in the general intensive care unit(ICU)of a TCM hospital.Methods:Clinical data of patients with EB-BSI admitted to the Department of Critical Care Medicine,Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University from July 2016 to January 2025 were retrospectively analyzed.The TCM-WM clinical characteristics of EB-BSI were summarized.Taking survival status at 28 days after onset as the end-point for prognosis evaluation,binary logistic regression analysis was used to identify independent risk factors for patient death.Results:Patients were aged 53 to 94 years,all with underlying diseases.Patients with syndrome of flaring heat in qifen and yingfen accounted for 60.3%.Compared with the survival group,the death group had more cases of altered mental status,cold extremities,and abnormal bowel sounds(P<0.05),and fewer cases of chills(P<0.05).Compared with other bacterial infections,patients with Klebsiella pneumoniae Bloodstream Infec-tion(KPBSI)had characteristics such as advanced age,higher 28-day mortality,longer time from ICU admission to onset,and higher proportion of Carbapenem-Resistant Enterobacteriaceae(CRE)infection.Multivariate analysis showed that increased SOFA score,altered mental status and deep vein catheterization were independent risk fac-tors for 28-day death in ICU patients with EB-BSI.Conclusion:Most EB-BSI patients in the general ICU of a TCM hospital present with syndrome of flaring heat in qifen and yingfen.KPBSI has a higher mortality rate than other EB-BSI.Altered mental status,deep vein catheterization and increased SOFA scores at the time of EB-BSI occurrence in the ICU are independent risk factors for 28-day death.