正确开展TORCH检测,降低出生缺陷风险OA
Conducting TORCH testing correctly to reduce the risk of birth defects
TORCH感染是导致出生缺陷的原因之一,目前尚缺乏有效的治疗手段,加强孕前、产前TORCH感染监测及正确诊断至关重要.TORCH感染的血清学筛查指标包括特异性IgM、IgG和IgG抗体亲和力,其可用于感染筛查和免疫状态的评估.推荐孕前进行TORCH感染的血清学筛查.妊娠期不推荐低风险的孕妇常规进行TORCH感染的血清学筛查,但建议有指征的孕妇进行筛查.疑似母体感染的临床征象以及某些超声检查的异常结果可为发现宫内感染提供线索,对是否进行侵入性产前诊断具有指导作用.明确的胎儿宫内感染,有无结构异常对于判断胎儿预后至关重要.胎儿TORCH感染的超声表现缺乏特异性,可以累及多脏器,母体病毒感染后胎儿受累程度不同.胎儿血液分析在识别胎儿感染的风险和胎儿预后方面具有附加价值.对于TORCH感染病例应加强母胎管理.
TORCH infection is one of the causes of birth defects,and there is currently a lack of effective treatment options.Strengthening preconception and prenatal TORCH infection surveillance and making accurate diagnosis are crucial.Serological screening markers for TORCH infection include specific IgM,IgG,and IgG antibody affinity,which are used for infection screening and immune status assessment.Preconception TORCH serological screening is recommended.Routine TORCH serological screening is not recommended for low-risk pregnant women during pregnancy,but TORCH testing is advised when indicated.Clinical signs of suspected maternal infection and certain abnormal ultrasound findings provide clues for detecting intrauterine infection and guide the decision on invasive prenatal diagnosis.Clear intrauterine fetal infection and the presence of structural abnormalities are critical for assessing fetal prognosis.The ultrasound findings of fetal TORCH infection lack specificity and can involve multiple organs,with varying degrees of fetal involvement after maternal viral infection.Fetal blood analysis has additional value in identifying the risk of fetal infection and assessing fetal prognosis.
连岩;王谢桐
青岛大学附属山东省妇幼保健院产科,山东济南 250014||国家卫生健康委母胎医学重点实验室,山东济南 250014青岛大学附属山东省妇幼保健院产科,山东济南 250014||国家卫生健康委母胎医学重点实验室,山东济南 250014||山东第一医科大学附属省立医院,山东济南 250021
医药卫生
TORCH感染血清学筛查产前诊断胎儿预后出生缺陷
TORCH infectionserological screeningprenatal diagnosisfetal prognosisbirth defects
《中国实用妇科与产科杂志》 2026 (2)
150-154,5
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