Metabolic engineering of SLC38A2 reprograms glutamine utilization and enhances CAR-macrophage antitumor function in solid tumorsOA
Metabolic engineering of SLC38A2 reprograms glutamine utilization and enhances CAR-macrophage antitumor function in solid tumors
Mingzhu Liu;Qiyi Zhao;Qingxi Chen;Luoling Zhang;Yunxuan Zhou;Ning Wen;Jin Jin;Junchao Cai;Shicheng Su;Jiang Li
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Medical Research Center,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China||Breast Tumor Center,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China||Department of Infectious Diseases,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China||Guangdong Provincial Key Laboratory of Liver Disease Research,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China||Laboratory of Clinical Microbiology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,ChinaDepartment of Infectious Diseases,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China||Guangdong Provincial Key Laboratory of Liver Disease Research,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China||Laboratory of Clinical Microbiology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,ChinaDepartment of Infectious Diseases,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China||Guangdong Provincial Key Laboratory of Liver Disease Research,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,ChinaDepartment of Infectious Diseases,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China||Guangdong Provincial Key Laboratory of Liver Disease Research,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,ChinaDepartment of Infectious Diseases,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China||Guangdong Provincial Key Laboratory of Liver Disease Research,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,ChinaDepartment of Infectious Diseases,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China||Guangdong Provincial Key Laboratory of Liver Disease Research,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,ChinaCenter for Neuroimmunology and Health Longevity,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,ChinaDepartment of Immunology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,ChinaGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Medical Research Center,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China||Breast Tumor Center,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,ChinaGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Medical Research Center,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China||Breast Tumor Center,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China
CAR-macrophagemetabolic engineeringSLC38A2glutamine metabolism
CAR-macrophagemetabolic engineeringSLC38A2glutamine metabolism
《癌症生物学与医学（英文版）》 2026 (3)
392-417,26
This work was supported by grants from the National Key R&D Program of China(Grant Nos.2021YFA1103000 and 2021YFA1302000),National Natural Science Foundation of China(Grant Nos.82572106,82125017,and 92359302),Guangdong Province Youth Top Talent Special Pillar Program 2024,Natural Science Foundation of Guangdong Province(Grant No.2314050001076),Guangdong Basic and Applied Basic Research Foundation(Grant Nos.2023A1515011033,2024B1515040006,and 2025A1515012431),Guangdong Major Project of Basic Research(Grant No.2023B0303000018),Guangzhou Science and Technology Plan Project(Grant No.2025B03J0063),Noncommunicable Chronic Diseases-National Science and Technology Major Project(Grant No.2025ZD0544000),Guangdong Provincial Clinical Research Center for Breast Diseases(Grant No.2023B110005),the Science and Technology Program of Guangzhou(Grant No.2024A04J6568),New Cornerstone Science Foundation through the New Cornerstone Investigator Program,and XPLORER PRIZE.
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