裸花紫珠颗粒治疗肝硬化门静脉高压性胃病的临床效果OA

Objective To investigate the clinical effect of Callicarpa nudiflora granules in the treatment of cirrhotic portal hypertensive gastropathy.Methods A total of 60 patients diagnosed with cirrhotic PHG were enrolled as research subjects and randomly divided into a control group or an observation group,with 30 patients in each group.The control group received conventional symptomatic treatment including oral propranolol hydrochloride tablets and esomeprazole magnesium enteric-coated tablets,based on which the observation group was additionally treated with Callicarpa nudiflora granules,and both groups were treated continuously for 2 courses(6 months in total).The endoscopic efficacy,histopathological changes of the gastric mucosa,liver function indicators(alanine aminotransferase[ALT],aspartate aminotransferase[AST]),and comprehensive clinical efficacy were compared between the two groups.Results After 6 months of treatment,the total endoscopic effective rate of the observation group was 93.33%(28/30),which was higher than the 63.33%(19/30)of the control group,with a statistically significant difference(P＜0.05);in the observation group,endoscopic mucosal hyperemia,edema,and mosaic-like lesions were significantly alleviated,and pathological changes such as gastric mucosal erosion and bleeding were improved compared with those before treatment and those in the control group.After 6 months of treatment,the serum levels of ALT and AST in the observation group were lower than those in the control group(all P＜0.05).After 6 months of treatment,the total clinical effective rate of the observation group was 93.33%(28/30),which was higher than the 70.00%(21/30)of the control group,with a statistically significant difference(P＜0.05).Conclusion Callicarpa nudiflora granules can effectively improve gastric mucosal lesions in patients with cirrhotic PHG,promote mucosal repair,and synergistically improve liver function,with significant clinical efficacy.