Integrative multi-omic analysis identified ERBB2 mutations and senescence-driven immune suppression as dual therapeutic targets in LAR triple-negative breast cancerOA
Integrative multi-omic analysis identified ERBB2 mutations and senescence-driven immune suppression as dual therapeutic targets in LAR triple-negative breast cancer
Yaxin Zhao;Han Wang;Ying Wang;Yizhou Jiang;Xin Hu;Zhiming Shao
Key Laboratory of Breast Cancer in Shanghai,Department of Breast Surgery,Fudan University Shanghai Cancer Center,Shanghai 200032,China||Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,ChinaKey Laboratory of Breast Cancer in Shanghai,Department of Breast Surgery,Fudan University Shanghai Cancer Center,Shanghai 200032,ChinaKey Laboratory of Breast Cancer in Shanghai,Department of Breast Surgery,Fudan University Shanghai Cancer Center,Shanghai 200032,ChinaKey Laboratory of Breast Cancer in Shanghai,Department of Breast Surgery,Fudan University Shanghai Cancer Center,Shanghai 200032,China||Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,ChinaKey Laboratory of Breast Cancer in Shanghai,Department of Breast Surgery,Fudan University Shanghai Cancer Center,Shanghai 200032,China||Precision Cancer Medical Center Affiliated to Fudan University Shanghai Cancer Center,Shanghai 201315,ChinaKey Laboratory of Breast Cancer in Shanghai,Department of Breast Surgery,Fudan University Shanghai Cancer Center,Shanghai 200032,China||Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China
Triple-negative breast cancerluminal androgen receptor subtypeERBB2 mutationcellular senescenceimmunotherapy resistance
Triple-negative breast cancerluminal androgen receptor subtypeERBB2 mutationcellular senescenceimmunotherapy resistance
《癌症生物学与医学（英文版）》 2026 (3)
374-391,18
This work received funding from the Ministry of Science and Technology of China(Grant Nos.2023YFF1205003,2023YFF0613304,and 2023YFC3402504),the National Key R&D Program of China(Grant No.2023YFF0613300,2023YFF1205003),and the National Natural Science Foundation of China(Grant Nos.82473499,82272957,and 82303735).
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