BEX2 influences the MCL1-Hedgehog signaling axis to regulate the potential of stemness characterization in colorectal cancerOA
BEX2 influences the MCL1-Hedgehog signaling axis to regulate the potential of stemness characterization in colorectal cancer
Yucheng Qian;Tianyi Ling;Qian Xiao;Kefeng Ding;Yeting Hu;Jingsun Wei;Yuan Bian;Yinuo Tan;Yimin Fang;Liubo Chen;Kai Jiang;Dongliang Fu;Xiaoxu Ge
Department of Colorectal Surgery and Oncology(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Key Laboratory of Molecular Biology in Medical Sciences,Zhejiang Province,China),The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310000,China||Center for Medical Research and Innovation in Digestive System Tumors,Ministry of Education,Hangzhou 310000,China||Zhejiang Provincial Clinical Research Center for CANCER,Hangzhou 310000,China||Cancer Center of Zhejiang University,Hangzhou 310000,ChinaDepartment of Colorectal Surgery and Oncology(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Key Laboratory of Molecular Biology in Medical Sciences,Zhejiang Province,China),The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310000,China||Center for Medical Research and Innovation in Digestive System Tumors,Ministry of Education,Hangzhou 310000,China||Zhejiang Provincial Clinical Research Center for CANCER,Hangzhou 310000,China||Cancer Center of Zhejiang University,Hangzhou 310000,ChinaDepartment of Colorectal Surgery and Oncology(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Key Laboratory of Molecular Biology in Medical Sciences,Zhejiang Province,China),The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310000,China||Center for Medical Research and Innovation in Digestive System Tumors,Ministry of Education,Hangzhou 310000,China||Zhejiang Provincial Clinical Research Center for CANCER,Hangzhou 310000,China||Cancer Center of Zhejiang University,Hangzhou 310000,ChinaDepartment of Colorectal Surgery and Oncology(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Key Laboratory of Molecular Biology in Medical Sciences,Zhejiang Province,China),The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310000,China||Center for Medical Research and Innovation in Digestive System Tumors,Ministry of Education,Hangzhou 310000,China||Zhejiang Provincial Clinical Research Center for CANCER,Hangzhou 310000,China||Cancer Center of Zhejiang University,Hangzhou 310000,ChinaDepartment of Colorectal Surgery and Oncology(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Key Laboratory of Molecular Biology in Medical Sciences,Zhejiang Province,China),The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310000,China||Center for Medical Research and Innovation in Digestive System Tumors,Ministry of Education,Hangzhou 310000,China||Zhejiang Provincial Clinical Research Center for CANCER,Hangzhou 310000,China||Cancer Center of Zhejiang University,Hangzhou 310000,ChinaDepartment of Colorectal Surgery and Oncology(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Key Laboratory of Molecular Biology in Medical Sciences,Zhejiang Province,China),The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310000,China||Center for Medical Research and Innovation in Digestive System Tumors,Ministry of Education,Hangzhou 310000,China||Zhejiang Provincial Clinical Research Center for CANCER,Hangzhou 310000,China||Cancer Center of Zhejiang University,Hangzhou 310000,ChinaDepartment of Colorectal Surgery,Shaoxing Central Hospital,Shaoxing 312030,ChinaCenter for Medical Research and Innovation in Digestive System Tumors,Ministry of Education,Hangzhou 310000,China||Zhejiang Provincial Clinical Research Center for CANCER,Hangzhou 310000,China||Cancer Center of Zhejiang University,Hangzhou 310000,China||Department of Medical Oncology,Key Laboratory of Cancer Prevention and Intervention,Ministry of Education,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,ChinaDepartment of Colorectal Surgery and Oncology(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Key Laboratory of Molecular Biology in Medical Sciences,Zhejiang Province,China),The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310000,China||Center for Medical Research and Innovation in Digestive System Tumors,Ministry of Education,Hangzhou 310000,China||Zhejiang Provincial Clinical Research Center for CANCER,Hangzhou 310000,China||Cancer Center of Zhejiang University,Hangzhou 310000,ChinaDepartment of Colorectal Surgery and Oncology(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Key Laboratory of Molecular Biology in Medical Sciences,Zhejiang Province,China),The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310000,China||Center for Medical Research and Innovation in Digestive System Tumors,Ministry of Education,Hangzhou 310000,China||Zhejiang Provincial Clinical Research Center for CANCER,Hangzhou 310000,China||Cancer Center of Zhejiang University,Hangzhou 310000,ChinaDepartment of Colorectal Surgery and Oncology(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Key Laboratory of Molecular Biology in Medical Sciences,Zhejiang Province,China),The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310000,China||Center for Medical Research and Innovation in Digestive System Tumors,Ministry of Education,Hangzhou 310000,China||Zhejiang Provincial Clinical Research Center for CANCER,Hangzhou 310000,China||Cancer Center of Zhejiang University,Hangzhou 310000,ChinaDepartment of Colorectal Surgery and Oncology(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Key Laboratory of Molecular Biology in Medical Sciences,Zhejiang Province,China),The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310000,China||Center for Medical Research and Innovation in Digestive System Tumors,Ministry of Education,Hangzhou 310000,China||Zhejiang Provincial Clinical Research Center for CANCER,Hangzhou 310000,China||Cancer Center of Zhejiang University,Hangzhou 310000,ChinaDepartment of Colorectal Surgery and Oncology(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Key Laboratory of Molecular Biology in Medical Sciences,Zhejiang Province,China),The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310000,China||Center for Medical Research and Innovation in Digestive System Tumors,Ministry of Education,Hangzhou 310000,China||Zhejiang Provincial Clinical Research Center for CANCER,Hangzhou 310000,China||Cancer Center of Zhejiang University,Hangzhou 310000,China
Cancer stemnessBEX2MCL1Hedgehog
Cancer stemnessBEX2MCL1Hedgehog
《癌症生物学与医学（英文版）》 2026 (2)
276-293,18
This research was supported by the National Natural Science Foundation(Grant No.81802750,82072624,and 82102708),Fundamental Research Funds for the Central Universities(Grant No.226-2024-00176),Zhejiang Provincial Natural Science Foundation of China(Grant No.LMS25H160014),and Zhejiang Provincial Medicine and Technology Projects Grant(Grant No.2020RC063).
评论